Neurol. pro Praxi, 2003; 1: 35-37

Dopaminergní léčba a její vliv na sexuální dysfunkce u pacientů s Parkinsonovou nemocí

MUDr. Michal Pohanka1, prof. MUDr. Petr Kaňovský CSc2, MUDr. Jiří Pulkrábek3
1 Sexuologické oddělení LF MU, FN u sv. Anny v Brně
2 Neurologická klinika FN a LF UP Olomouc
3 I. neurologická klinika LF MU a FN u sv. Anny Brno

Keywords: Parkinsonova nemoc, sexuální dyfunkce, dopaminergní terapie.

Published: December 31, 2003  Show citation

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Pohanka M, Kaňovský P, Pulkrábek J. Dopaminergní léčba a její vliv na sexuální dysfunkce u pacientů s Parkinsonovou nemocí. Neurol. praxi. 2003;4(1):35-37.

Sexuální dysfunkce postihují většinu pacientů trpících Parkinsonovou nemocí, muže i ženy, a to až u 50-70% nemocných. Spektrum poruch je velmi široké, od ztráty apetence, snížení libida, až po vyhasnutí erektilní funkce nebo neschopnost vaginální lubrikace. Klasická sexuologická léčba často selhává, zejména u žen, kde nelze použít léky k léčbě erektilní dysfunkce, jako je např. sildenafil. Dopaminergní medikace, tj. podávání L-DOPA nebo agonistů dopaminu, se však ukazuje mít pozitivní účinek na tyto invalidizující symptomy Parkinsonovy nemoci. Zároveň však je schopna vyvolat u některých pacientů hypersexualitu. Tyto efekty dopaminergní medikace je potřeba znát a cíleně s nimi pracovat, zejména ve skupinách mladších pacientů se zachovanou sexuální aktivitou, nebo u těch, kteří se o zachování snaží.

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    References

    1. Brown E, Brown GM, Kofman O, Quarrington B. Sexual function and affect in parkinsonian men treated with L-DOPA. Am J Psychiatr 1978; 135: 1552-1555. Go to original source... Go to PubMed...
    2. Brown RG, Jahanshahi M, Quinn N, Marsden CD. Sexual dysfunction in patients with Parkinson´s disease and their partners. J Neurol Neurosurg Psychiatr 1990; 53: 480-486. Go to original source... Go to PubMed...
    3. Wermuth L, Stenager E. Sexual problems in young patients with Parkinson´s disease. Acta Neurol Scand 1995; 91: 453-455. Go to original source... Go to PubMed...
    4. Lambert D, Waters CH. Sexual dysfunction in Parkinson´s disease. Clin Neurosci 1998; 5: 73-77. Go to PubMed...
    5. Posen J, Moore O, Tassa DS, Ginzburg K, Drory M, Giladi N. Young women with PD: a group work experience. Soc Work Helat Care 2000; 32: 77-91. Go to original source... Go to PubMed...
    6. Moore O, Gurevich T, Korczyn AD, Anca M, Shabtai H, Giladi N. Quality of sexual life in Parkinson´s disease. Parkinsonism Relat Disord 2002; 8: 243-246. Go to original source... Go to PubMed...
    7. Uitti RJ, Tanner CM, Rajput AH, Goetz CG, Klawans HL, Thiessen B. Hypersexuality with antiparkinsonian therapy. Clin Neuropharmacol 1989; 12: 375-383. Go to original source... Go to PubMed...
    8. Weinman E, Ruskin PE. Levodopa dependence and hypersexuality in older Parkinson´s disease patients. Am J Ger Psych 1995; 3: 81-83. Go to original source...
    9. Cummings JL. Behavioral complications of drug treatment in Parkinson´s disease. J Am Ger Soc 1991; 39: 708-716. Go to original source... Go to PubMed...
    10. Rosen RC, Ashton AK. Prosexual drugs: empirical status of the, ,new aphrodisiacs". Arch Sex Behav 1993; 22: 521-543. Go to original source... Go to PubMed...
    11. Melis MR, Argiolas A. Dopamine and sexual behavior. Neurosci Biobehav Rev 1995; 19: 19-38. Go to original source... Go to PubMed...
    12. O´Sullivan JD, Hughes AJ. Apomorphine-induced penile erections in Parkinson´s disease. Mov Disord 1998; 13: 536-539. Go to original source... Go to PubMed...
    13. Fine J, Lang AE. Dose-induced penile erections in response to ropinirole therapy for Parkinson´s disease. Mov Disord 1999, 14: 701-702. Go to original source... Go to PubMed...
    14. Jimenez-Jimenez FJ, Tallon-Barranco A. Fluctuating penile erections related with levodopa therapy. Neurology 1999; 52: 210-212. Go to original source... Go to PubMed...
    15. Kaňovský P, Bareš M, Pohanka M, Rektor I. Penile erections and hypersexuality induced by pergolide treatment in advanced, fluctuating Parkinson´s disease. J Neurol 2002; 249: 112-114. Go to original source... Go to PubMed...
    16. Raffaele R, Vecchio I, Giamusso B, Morgia G, Brunetto MB, Rampello L. Efficacy and safety of fixed-dose oral sildenafil in the treatment of sexual dysfunction in depressed patients with idiopathic Parkinson´s disease. Eur Urol 2002, 41; 382-386. Go to original source... Go to PubMed...

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