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NEUROLOGIE3418040010757101158205267310370429450493
PRO856804001074591154
PRAXI1031804001074591148201221
/12988040010731
Neurol.1374804001075593139165209227243
praxi.1633804001074672114152170186
2025;26(3):192-1961836804001074487128172185229272295338359373411449490516554592637
/25188040010731
www.neurologiepropraxi.cz460880400107651332012142633073553814284484965465656086586857327828098518919109269661005
1961298020012657111169
HLAVNÍ341200012670127198263336370
TÉMA733200012657114204274
Hodnocení34136001063980120161202237269310328
účinnosti6853600106387391132173214246279297
léčby9983600106286196132168
roztroušené118236001063374105139175215257289320362393
sklerózy15913600106316697130166206238276
v1883360010636
praxi,193536001063368110148165181
vývoj213136001063675115155178
konceptu232436001063473114149181216248289
NEDA262936001063971111149
25;15:17562864211066751.340550083347081111142153183213246281315349384421454486514546582618652685716726
doi:1087550083387792105
10.1177/17562864211066751.1213550083346679110138168203223257286320354388422458495528560588620656692725758790799
PMID:3406500833589104150163
35096143;5196500833467101136171202233265277
PMCID:8116500833589129144190203
PMC8793117.10306500833588129164197230263294321351357
4.3407500853651
Giovannoni404750083445997129162199237275314329
G,7467500834357
Tomic8157500833367125140172
D,10007500834556
Bright1069750083355672110148170
JR,1251750083256074
Havrdová13387500834476108130168206238270
E.16217500833346
"No16807500832166105
evident1797750083346682121156194215
disease340850083375277111141167201
activity":553850083316285100131146168200222232
The7978500833270104
use912850083376296
of10208500833655
combined10878500833066123161175212246284
assessments1383850083315782116142168224258294315342
in17378500831451
the1799850083225992
management190385008356883409500833769108143200235273294
of6479500833756
patients716950083387193108142180201229
with958950083506588126
multiple10969500835795110132147186202236
sclerosis.1345950083265873108129166192207233246
Mult16049500835388103124
Scler.1738950083316074105125135
20171884950083346899129
Aug;23(9):1179-1187.34010500834076114125159192210241258269298325353385408438464494526532
doi:8831050083387589101
10.1177/1352458517703193.9951050083346476106132161194213245274306338369400433466496524558590622652681712724
Epub173110500833269106144
201718871050083336697125
Apr34011500834180102
6.45711500833448
PMID:52011500833589104150163
28381105;69811500833568102137169196228262273
PMCID:98611500833589129144190203
PMC5536258.120411500833689130166198231266299334368381
5.34012500853752
Havrdová41312500834578111133172212245278
E,71312500833347
a781125008332
kol.829125008331698699
Roztroušená94912500833676105130152190230257292331365
skleróza,13351250083275775110132171200234247
MF160412500835589
2013,171412500833570103134146
ISBN18821250083154884130
978-80-204-3154-7.34013500833467100123159194218249283319342375406436471494525531
6.34014500853753
Havrdová41414500834578110133172211244278
E,71314500833347
Arnold78114500834264103143159199
DL,10011450083467993
Bar-Or11161450083367091112163185
A,132214500834257
et140014500833557
al.14791450083324861
No156214500834584
evidence16681450083346784123159198231266
of195514500833858
disease3401550083395684121154183220
activity5881550083336793109144161185221
(NEDA)83715500831966101149191211
analysis107715500833272107123157186202230
by133515500834073
epochs143615500833577118152192220
in168515500831555
patients17681550083407598115151192215244
with3401650083516689127
relapsing4881650083215570103142169184222261
multiple77016500835795110133148188204238
sclerosis10291650083265974109130168195210236
treated12851650083224478110132166205
with15111650083506689127
ocrelizumab16591650083377091125141156185224282314354
vs34017500833260
interferon4211750083155476110132154189211249289
beta-1a.7311750083397598132155187216229
Mult98217500835491106127
Scler11261750083326277108129
J1272175008325
Exp13141750083316299
Transl14301750083324983121145159
Clin.16071750083385368106119
2018174717500833570102134
Mar190217500835589110
12;4(1):2055217318760642.3401850083356578113133165180192228263298331365397427461493525558591627663700733746
doi:11071850083397894106
10.1177/2055217318760642.12341850083356780111139169204225260295330363397429459493525557590623659695732766778
PMID:34019500833589104150163
29568544;51919500833468102136172206241278290
PMCID:82419500833589129144190203
PMC5858626.104319500833588129165199233267302336369383
7.34020500853645
Havrdova40620500834477109131169208240273
E,69920500833346
Galetta7662050083447792127150174207
S,99420500833346
Hutchinson106020500834482105136174190228254293331
M,141220500835568
et150120500833456
al.15782050083324861
Effect16592050083335271106139163
of184320500833756
natalizumab192020500833870340215008322567388119158218252292
on65421500833878
clinical7542150083324864103119152186203
and97821500833372113
radiological11132150083215596112151168207248264298332348
disease14832150083395582118151179216
activity17202150083336691108141158181217
in195821500831555
multiple34022500835896112134150189206241
sclerosis:6022250083265974109131169196211237250
a873225008332
retrospective921225008320557899137164204240273297313346380
analysis132222500833271103119151179194220
of156322500833857
the16412250083226096
Natalizumab17582250083457710013314816419323234023500835992132
Safety4942350083336786122145180
and69523500833372112
Efficacy828235008334527089122156189223
in107323500831554
Relapsing-Remitting11482350083367289122162190205244284307346382441457480505521560601
Multiple177023500835695111134150190207242
Sclerosis3402450083336581116138175202218244
(AFFIRM)6052450083196093126140177233251
study.8772450083265088128160170
Lancet106424500832965102132161183
Neurol.126424500834373110131166181194
2009148024500833469105141
Mar;8(3):25460.1642245008355881091231581782122292412773123483402550083357184
doi:4462550083387894106
10.1016/S1474-4422(09)70021-3.5742550083356780112144177209235268300332365396420458496529565583618654672705739776810842861895908
Epub150325500833373113153
2009167725500833570107143
Feb184125500833368109
7.197125500833541
PMID:34026500833589104150163
19201654.5192650083346497131163194228263276
8.34027500853652
Havrdova41327500834477109131170209241275
E,70827500833347
Giovannoni7752750083446099131164203241280319334
G,113027500834458
Stefoski12092750083335488108146173203220
D,145027500834556
et152727500833457
al.16052750083324861
Disease-activity-free16872750083456188123155182218241274306340285008322377086109143165185207241277
status6382850083264982104143169
in82828500831453
patients9012850083397294110145183205233
with11552850083506689127
relapsing-remitting13032850083215571103143170185223262285307341400415438462478516555
multiple187928500835795111340295008322377793128
sclerosis4892950083275975110132169197212238
treated7482950083224478110132167207
with9752950083516790129
daclizumab112529500833871103119134164202261294333
high-yield14792950083385393131154186202237253293
process17922950083396199132166194221
in34030500831553
the4143050083226197
SELECT5323050083336597131172209
study.7623050083265088128160171
Mult95030500835390105126
Scler.10943050083316176106128138
2014125030500833569102133
Apr;20(4):464-70.140430500834282104118153188208241259271306343380404436469482
doi:19073050083397793106
10.1177/1352458513502113.3403150083336476105132160194213245274306338369400433466496525557590622652679708720
Epub107131500833270107145
201312283150083336697126
Sep136631500833165103
10.14813150083346476
PMID:156931500833486101145158
24022270.17393150083336499130164198230262273
9.21405500853751
Kappos22165500833671112154194222
L,24635500833247
De25345500834683
Stefano2642550083335591111146186226
N,28925500834660
Freedman2976550083345490127169229263303
MS,33035500835691104
et34315500833559
al.3514550083334963
Inclusion360255008315548810514417218821406500833878
of22406500833959
brain2321650083406397113153
volume2495650083337289128188225
loss2742650083155583111
in28746500831655
a295165008333
revised3000650083225791108135172213
measure32356500835995129156195217253
of35106500833859
'no3591650083125191
evidence370465008335698521407500833976116150186
of23537500833960
disease2440750083395684121154183220
activity'2687750083336793109144161185221236
(NEDA-4)29507500831967102149191214253272
in32497500831555
relapsing-remitting33327500832157741081491781942342752993223584194354602140850083223775114
multiple22758500835795111133148188204239
sclerosis.2534850083275974109131168195210236250
Mult28048500835389104125
Scler.2946850083316075105126137
201631008500833468100132
Sep;22(10):1297-305.32528500833368107120155190207239271289301331361395428447480514549561
doi:2140950083397995108
10.1177/1352458515616701.2270950083356881113142173208229264295330364397431467502535566602633666700734768778
Epub30699500833474114155
201532459500833571104135
Nov34029500834686119
19.3543950083356678
PMID:36439500833692108155169
26585439;214010500833468102136170205237271284
PMCID:243910500833589129144190203
PMC5015759.265710500833689130166200231261295328360371
10.21401150085367085
Kappos224011500833568108147186213
L,246811500833245
Wolinsky252911500835794110125162189219253
JS,27971150083245669
Giovannoni28811150083446098129162200238277315330
G,322711500834357
et329911500833457
al.33711150083324760
Contribution344711500834077115137158174213251274289327365
of214012500833757
Relapse-Independent22111250083357086118157184219242258296335370410445483522557595617
Progression28421250083355693133154188215241256294332
vs318912500833158
Relapse-Associated32611250083367186118158184219242284312338376409424456478512551
Worsening214013500835794115143178216231269308
to246313500832259
Overall253713500834780115136169184199
Confirmed275213500833976115132149170229264303
Disability30711350083456087120159174190205227261
Accumulation334713500834172103141199237252284306321359398
in376013500831452
Typical214014500833360100116148181196
Relapsing23491450083367186118158184199237276
Multiple263814500835593108130146185201236
Sclerosis28871450083326580115136173200215241
in314114500831553
a3207145008332
Pooled325414500833572111127162201
Analysis346814500834180112127159186201227
of370814500833857
23778145008334
Randomized214015500833567104142179236251279313351
Clinical25031550083405469106120151183198
Trials.2713155008333496495110136149
JAMA287415500832460112149
Neurol.303315500834372108127161176189
202032321550083346799132
Sep337615500833267105
1;77(9):11321140.3493155008334417410712315517218421323926930021401650083346191126138
doi:22901650083387590102
10.1001/jamaneurol.2020.1568.24041650083346476106137172204225240272328360397431468489525541553588622654687699729758792827839
PMID:325616500833487102147159
32511687;342716500833466100130157188222255264
PMCID:370316500833587214017500834055101114
PMC7281382.226917500833589129164199232264294329362375
11.21401850085366678
Lebrun-Frénay223818500833166105126165203225259279313351383414
C,267218500834053
Siva27451850083324780113
A,287818500834055
Sormani29531850083327092150183221236
MP,32091850083549095
et332418500833456
al.34001850083324760
TERIS348018500833267102118150
Study36501850083325491131162
Group.214019500834465103141180192
Teriflunomide23461950083326384100118135172210249307322361396
and275519500833270109
Time287819500833249107142
to303419500832158
Clinical31061950083405570108123155188203
Multiple332319500835492107130145184200235
Sclerosis35721950083326480114136173200214241
in214020500831552
Patients22052050083356788103138176197225
With24432050083577395133
Radiologically258920500833568106121159175213252267299332347362393
Isolated2995205008315417995127148182221
Syndrome:322920500833262100139160197255290302
The354420500833372107
TERIS366320500833367102118150
Randomized214021500833566103141178234248276309348
Clinical24992150083395367104118149181195
Trial.2706215008332486393108120
JAMA283821500832359111148
Neurol.299521500834272107126160174187
202331912150083336698132
Oct333421500834677101
1;80(10):10801088.34462150083334175109128158188206217246276310344214022500833567103139153
doi:23142250083397893106
10.1001/jamaneurol.2023.2815.24412250083356780111143180213235252284343376415451489511549565579615650684719732769803836867879
PMID:334122500833690106153166
37603328;352822500833568100137170204237272284
PMCID:214023500833589129144190203
PMC10442780.235923500833588129161193229266298331365400413
12.21402450085366884
Okuda224424500834778116155187
DT,24522450083457786
Kantarci255924500833468106128160182213228
O,280724500834758
Lebrun-Frénay288624500833165105126164203225259279313351383414
C,332124500834053
et339424500833456
al.34712450083314760
Dimethyl355124500834561119154176214245261
Fumarate214025500833268126158179212234267
Delays24202550083458196128159186
Multiple261925500835492107129144183199234
Sclerosis28662550083326479114135172199214240
in311825500831553
Radiologically318425500833568106122159175213253268299332347362394
Isolated3591255008315417995127148182221
Syndrome.214026500833262101140161199257292304
Ann245826500833874111
Neurol.258026500834373109130165180193
2023278426500833468101136
Mar;93(3):604-614.293426500835487108121157189208241258270306341377400438468499511
doi:34592650083387692104
10.1002/35772650083346578109140176209236
ana.26555.214027500833270102115151185219251284296
Epub245127500833372110149
2022261527500833468101136
Dec276627500834681114
10.28952750083346678
PMID:298927500833588104150163
36401339.316727500833469105141173203236269280
13.21402850085366985
Phillips22402850083357389105121136176204
JT,24592850083245969
Giovannoni25432850083446098131165203242281320336
G,289428500834458
Lublin296728500833269109126142180
FD,31622850083337890
et326728500833457
al.33392850083324862
Sustained34162850083337198122155171210245285
improvement371728500831473214029500833962100133169228264304326
in248929500831453
Expanded256529500833366107141181221257298
Disability28852950083466290124164181197213237272
Status31792950083335589112151178
Scale338029500833266100116152
as355529500833259
a3637295008332
new368629500833874126
efficacy2140305008334547290124158192227
measure238930500835895128156195217253
of266430500833859
neurological274530500833875114136175192232273289323357374
change314130500833271105145185222
in338530500831554
multiple346230500835897114137154194212248
sclerosis:37323050083276121403150083155072110137152179192
treatment23463150083224478111133191227266288
effects26483150083345473108141165194
with28563150083506689128
natalizumab29983150083387093126142158187226284317357
in336931500831453
patients34363150083397294110145184206234
with36843150083516790129
relapsing3940550083215572105144172187226266
multiple42255500835795111134150190207242
sclerosis.4486550083275975111133171198214241255
Mult47605500835390105127
Scler.4902550083316177108129140
201150615500833469101130
Aug;17(8):9709.5210550083417811813116219220924326227531034437839406500833446
doi:4004650083387793106
10.1177/1352458511399611.4127650083356780111140170205226260290324358390424459493525554584618654690721750760
Epub49056500833272111151
201150736500833569102130
Mar52216500835488110
18.5348650083356680
PMID:54466500833590106153166
21421809.3940750083346698131163195231267279
14.3940850085366984
Polman4041850083357288145178216
CH,4273850083408597
O'Connor43878500834760100137176214252273
PW,46778500833593103
Havrdova47978500834476108130168206238271
E,50848500833346
et51478500833456
al.;522085008332476073
AFFIRM53098500834174106120156212
Investigators.553785008315533940950083326693116131170202224261283310323
A427995008341
randomized,4335950083215492131169227242271306345358
placebo-controlled4708950083395587119153192231254288325363385406443459474509549
trial527295008322435991106
of53949500833756
natalizumab54669500833769911243940105008315305997155187227
for41861050083185678
relapsing42831050083215571103142169183221260
multiple456310500835795110133148187203238
sclerosis.48201050083265974109130167194209235248
N5088105008343
Engl514710500833167102117
J5280105008324
Med.532010500835383119133
2006547210500833468104140
Mar394011500835690112
2;354(9):899-910.40741150083354884118155175209228241277313349374410444476490
doi:45851150083407995108
10.1056/NEJMoa044397.47151150083356881113146181217243291325353410450484521559597631665700706
PMID:544311500833692108156169
16510744.39401250083346599130162194225262274
15.39401350085366883
Rotstein40441350083357496124147181196234
DL,42981350083467892
Healy441013500834479111127159
BC,45891350083367689
Malik469913500835587103118148
MT,48671350083558897
et498513500833456
al.50621350083314760
Evaluation51421350083336598113151183205220259297
of546013500833756
no553713500833776
evidence39401450083346782122157195227261
of422214500833757
disease42991450083385480115147174209
activity45291450083326488104137152175209
in475914500831452
a4832145008332
7-year48791450083355385120152173
longitudinal50731450083155392131146169207246262300332348
multiple54411450083589611113414939401550083395589
sclerosis40491550083265974109130167194209235
cohort.430415500833168107145166191204
JAMA452915500832461114152
Neurol.469815500834373109130164179193
2015491015500833468100130
Feb;72(2):152-8.506015500833266106118151185202236254266296326359379415429
doi:55091550083387692104
10.1001/jamaneurol.2014.3537.39401650083346678109140177208230246278336369407442479500538554566603637668699712747780813846852
16.39401750085356883
Uher403517500834380114135
T,418217500833241
Havrdova423517500834375106127164201232265
EK,45121750083326680
Benkert460417500833569107136169190214
P,483017500833539
et488117500833355
al.49481750083314659
Measurement501917500835488119145181202235291326363384
of541517500833755
neurofilaments5482175008337721083940185008321587693108140198233271292320
improves427518500831573112133171202237264
stratification45541850083264970103125140158175207240262277315353
of492318500833756
future49941850083185780118139173
disease51821850083385379114146173208
activity54051850083326488103136151174208
in394019500831553
early40131950083356788104136
multiple416919500835896111134149189205240
sclerosis.44291950083275975110131169195210237250
Mult470019500835389104125
Scler.48421950083316175106127137
2021499719500833469102133
Nov;27(13):20012013.51511950083458311612916419721424627629330534137541144339402050083346798127139
doi:40912050083387590102
10.1177/13524585211047977.42052050083346476107133162196215248277309341373405438471504534561592627659691723757763
Epub498020500833270108146
202151382050083346799130
Oct528020500834678102
6.539420500833446
PMID:545320500833487102147159
34612753.394021500833470106136166199231265277
17.39402250085356675
Uher402722500834380114135
T,417422500833240
Havrdova422622500834475106127164202233265
E,450322500833245
Sobisek456022500833269108123148182212
L,478422500833144
et484022500833355
al.49072250083314658
Is497822500831439
no503022500833774
evidence51162250083336580118152189220253
of538122500833756
disease54492250083375277111142394023500832660
activity40122350083316286100132147169202
an422623500833168
achievable430623500833163100114148179211250265299
goal461723500833775107121
in475023500831552
MS481423500835386
patients49122350083387091105139176197224
on514823500833774
intramuscular5234235008315527293125182218244275312327358379
interferon39402450083155273107127149183204240278
beta-1a42312450083387496128150181209
treatment44522450083224377108129187222259281
over474524500833769103124
long-term48812450083155391129151173207228286
follow-up?5179245008318567186124174196235273298
Mult549024500835288103123
Scler.39402550083316074105125136
2017408625500833468100129
Feb;23(2):242-252.422825500833266105117152186204238256267302334366387417452485497
doi:47382550083387692104
10.1177/1352458516650525.48542550083346678109136165200220253282315348380412446480511542577611645679712746758
Epub394026500833372110149
2016410426500833468100131
Jul42512650083246277
11.43432650083356272
PMID:443026500833589104150163
27230790.460826500833568102137171204237273285
18.39402750085356884
University40362750083438095127160181208222244277
of432527500833756
California,43932750083407287101120157178216231262275
San468027500833264102
Francisco47942750083325183121152167192224260
MS-EPIC506727500835386108141176190230
Team,53092750083336394151163
Cree54842750083406094128
BAC,394028500833576115127
Hollenbach40802850083448298113147185224257289326
JA,44192850083246478
Bove451028500833573105139
R,466128500833649
e4723285008334
tal.4770285008321546982
Silent4865285008332466296134155
progression50332850083396097136157191218244259296334
in538028500831552
disease54452850083385379114145394029500832661
activity-free40142950083326488104136152174208230250272306341
relapsing43692950083205470102141168183221260
multiple464229500835795110133148187203238
sclerosis.48932950083265874109130167194209235248
Ann515529500833874111
Neurol.527729500834273109129164179192
2019548229500833468100130
May;85(5):653-666.394030500835588119132167202220253272284320354387409447483518532
doi:44923050083397793105
10.1002/ana.25463.46183050083346678109141178211238268307339353389424459496530542
Epub518130500833372111150
2019535230500833468100131
Mar550330500835588109
30.39403150083346981
PMID:403731500833588104150163
30851128;421531500833469104138169197227261273
PMCID:450331500833589129144190203
PMC6518998.472231500833588129163197228259293328363377
www.neuforum.cz368878700245150304458496611713825888999106911811349139614841576
6.49445700754344509
NEURO10974790047926848675699712781421
MUSKULÁRNÍ285522004793295998151066133615431811204723232446
FÓRUM844564004792074847259951328
2.–3.85875300289123171288404449
10.135875300289123232277
2025168675300289123241354474
Hotel92178000236131240309409462
Kraskov142178000236117190288369472578675
Třemošnice-Starý54380300236104175274438547628739790875973103811371203130413751478
Dvůr205980300236133234344416