Neurol. pro Praxi, 2003; 3: 116-120

Iatrogénna problematika antiepileptík

doc. MUDr. h. Vladimír Donáth PhD
Neurologické oddelenie, Nemocnica F.D. Roosevelta, Banská Bystrica

Published: December 31, 2003  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Donáth HV. Iatrogénna problematika antiepileptík. Neurol. praxi. 2003;4(3):116-120.

Iatrogénny dopad antiepileptík sa týka hlavne výberu antiepileptika, alebo jeho kombinácií, zhoršenia samotného epileptického problému, výskytu nežiaducich príznakov, ktoré komplikujú priebeh a klinický obraz a teratogenicity. Zhoršenie záchvatov antiepileptikami je závažný a častý problém, ktorý sa nezriedka prehliada. Najčastejšími príčinami býva nesprávna diagnóza záchvatov alebo syndrómov, nedostatok informácií o kontraindikáciach antiepileptík, nesprávna preskripcia dávok a kombinácií.

Kľúčové slová

epilepsia, antiepileptika, iatrogénny účinok, zhoršenie záchvatov.

Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Aarli JA. Immunological aspects of epilepsy. Brain Dev 1993; 15: 41-49. Go to original source... Go to PubMed...
    2. Bell WL, Crawford IL, Shiu GK. Reduced bioavailability of moisture-exposed carbamazepine resulting in status epilepticus. Epilepsia 1993; 34: 1102-1104. Go to original source... Go to PubMed...
    3. Berkovic SF. Aggravation of Generalized Epilepsies, Epilepsia, 1988; 39 (Suppl. 3):SI1-S14. Go to original source... Go to PubMed...
    4. Binnie CD. Lamotrigine. In: Engel J Jr, Pedley TA, eds. Epilepsy: A comprehensive textbook. Philadelphia, Lippincott-Raven Publishers, 1997: 1531-1540.
    5. Darchy B, Miére E, Figuérédo B, Bavoux E, Domart Y. Iatrogenic diseases as a reason for admission to the intensive care unit. Incidence, causes, and consequences. Arch Intern Med 1999; 159: 71-78. Go to original source... Go to PubMed...
    6. Elger CH E, et al. Aggravation of Focal Epileptic seizures by Antiepileptic Drugs. Epilepsia 1998; 39 (Suppl. 7): 15-18. Go to original source... Go to PubMed...
    7. Genton P, McMenamin J. Aggravation of Seizures by Antiepileptic Drugs. What to Do in Clinical Practice. Epilepsía 1998; 39 (Suppl. 3): 26-29. Go to original source... Go to PubMed...
    8. Guerrini R, Belmonte A, Strumia S, Hirsch E. Exacerbation of epileptic negative myoclonus by carbamazepine or phenobarbital in children with atypical benign rolandic epilepsy. Epilepsia 1995; 36 (Suppl 3): 65.
    9. Guerrini R, Belmonte A, Genton P. Antiepileptic drug-induced worsening of seizures in children. Epilepsia 1998; 39 (Suppl 3): 2-10. Go to original source... Go to PubMed...
    10. Jain KK. Lupus erythematosus like syndromes associated with carbamazepine therapy. Drug Safety 1991; 6: 350-360. Go to original source... Go to PubMed...
    11. Jain KK. Investigation and management of loss of efficacy of an antiepileptic medication using carbamazepine as an example. J Roy Soc Med 1993; 86: 133-136. Go to original source... Go to PubMed...
    12. Johnsen SD, Tarby TJ, Sidell AD. Carbamazepine-induced seizures. Ann Neurol 1984; 16: 392-393.
    13. Osorio I, Reed RC, Peltzer JN. Refractory idiopathic absence status epilepticus: a probable paradoxical effect of phenytoin and carbamazepine. Epilepsia 2000; 41: 887-894. Go to original source... Go to PubMed...
    14. Otoom S, Al-Hadidi H, Seizure induced by antiepileptic drugs. Annals of Saudi Medicine 2000; Vol 20, No 3-4: 316-318. Go to original source... Go to PubMed...
    15. Perucca E, Gram L, Avanzini G, et al. Antiepileptic drugs as a cause of worsening seizures. Epilepsia 1998; 39: 5-17. Go to original source... Go to PubMed...
    16. Shields WD, Saslow E. Myoclonic, atonic and absence seizures following institution of carbamazepine therapy in children. Neurology 1983; 33: 1487-1489. Go to original source... Go to PubMed...
    17. Steinhoff BJ, Stodiek SR. Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. Seizure 1993; 2: 261-265. Go to original source... Go to PubMed...
    18. Sýkora P, Sýkora J. Môžu antiepileptiká zhoršiť priebeh epilepsie? Farm obzor 1999; 68: 219-222.
    19. Todorov AB, Lenn NJ, Gabor AJ. Exacerbation of generalized nonconvulsive seizure with ethosuximide therapy. Arch Neurol 1978; 35: 389-391. Go to original source... Go to PubMed...
    20. Turski L, Niemann W, Stephens DN. Differential effects of antiepileptic drugs and ß-carbolines on seizures induced by excitatory amino acids. Neuroscience 1990; 39: 799-807. Go to original source... Go to PubMed...
    21. Yerby MS. Treatment of epilepsy during pregnancy. In: Wyllie E., ed. The treatment of epilepsy: Principles and practice, 2 nd ed. Baltimore, Williams & Wilkins; 1996: 785-798.

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.