Neurol. pro Praxi, 2004; 3: 172-175

Lokalizace korových řečových center a hodnocení jejich lateralizace pomocí funkční MRI

MUDr. Pavel Chlebus2,1, prof. MUDr. Milan Brázdil Ph.D1, Ing. Michal Mikl1, prof. MUDr. Ivan Rektor CSc1, MUDr. Marta Pažourková2, doc. MUDr. Petr Krupa CSc2
1 I. neurologická klinika LF MU a FN u sv. Anny Brno
2 Klinika zobrazovacích metod LF MU, FN u sv. Anny v Brně

Keywords: fMRI, VFT, řeč, lateralizační index.

Published: December 31, 2004  Show citation

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Chlebus P, Brázdil M, Mikl M, Rektor I, Pažourková M, Krupa P. Lokalizace korových řečových center a hodnocení jejich lateralizace pomocí funkční MRI. Neurol. praxi. 2004;7(3):172-175.

Funkční MRI je zobrazovací metoda, která se v poslední době dostává do povědomí širší lékařské veřejnosti. Rovněž dochází ke snaze o její využítí v klinických oborech. V této studii jsme se zaměřili na lokalizaci korových řečových center a určení řečově dominantní hemisféry pomocí tzv. lateralizačního indexu (LI) u zdravých dobrovolníků s pravostrannou motorickou dominancí. K aktivaci cerebrálních oblastí podílejících se na řečových funkcích byl užit test slovní plynulosti (VFT). Nejsignifikantnější změny MR signálu (dle rozsahu i statistické významnosti) byly patrny, ve shodě z předchozími studiemi, v levostranném g. frontalis inferior (Brocovo centrum řeči) a pravostranné mozečkové kůře. Dosud neúplně zodpovězena však zůstává otázka, s jakou spolehlivostí dokáže fMRI (respektive výpočet lateralizačního indexu) určit řečově dominantní hemisféru.

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