Neurol. pro Praxi, 2005; 4: 202-204

Periodické paralýzy

MUDr. František Cibulčík Ph.D
Neurologická klinika SZU a FNsP Bratislava-Ružinov

Periodické paralýzy sú väčšinou familiárne ochorenia charakterizované prechodnými stavmi svalovej slabosti kolísavého trvania a intenzity, ktoré nie sú sprevádzané poruchou vedomia, citlivosti ani koordinácie. Výsledky intenzívneho výskumu v posledných desaťročiach potvrdili genetický pôvod familiárnych foriem, pričom podstatou väčšiny z nich sú dnes už známe poruchy v kódovaní proteínov tvoriacich súčasť iónových kanálov lokalizovaných v membránach svalových buniek. Aj dnes sa však najčastejšie používa delenie týchto ochorení podľa sprievodných zmien hladiny kália v krvi počas záchvatu. Rozlišujeme tak skupinu hypokaliemických periodických paralýz, hyperkaliemickú periodickú paralýzu a periodické paralýzy s normálnou hladinou kália počas svalovej slabosti.

Keywords: Kľúčové slová: periodická paralýza, iónové kanály, tyreotoxikóza.

Published: February 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Cibulčík F. Periodické paralýzy. Neurol. praxi. 2005;6(4):202-204.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Ambler Z. Poruchy iontových kanálů. Čes. a slov. Neurol. Neurochir. 2000; 63/69: 203-208.
    2. Bednařík J. Poruchy svalové dráždivosti. In: Bednařík J, et al. Nemoci kosterního svalstva. Triton Praha, 2001: 198-226.
    3. Brancati F, Valente FM, Davies NP, et al. Severe infantile hyperkalemic periodic paralysis and paramyotonia congenita: broadening the clinical spectrum associated with the T704M mutation in SCN4A. J Neurol Neurosurg Psychiatry 2003; 74: 1339-1341. Go to original source... Go to PubMed...
    4. Buruma GJS, Schipperheyn JJ. Periodic paralysis. In: Vinken PJ, Bruyn GW. Handbook of clinical neurology. Elsevier Amsterrdam, 1979; Vol 41: 147-174.
    5. Ceé J. Thyrotoxic periodic paralysis. Čes. a slov. Neurol. Neurochir. 2004; 67/100: 49-51.
    6. Donaldson MR, Yoon G, Fu YH, Ptacek LJ. Andersen Tawil syndrome: a model of clinical variability, pleiotropy and genetic heterogenity. Ann Med 2004; Suppl 1: 92-97. Go to original source... Go to PubMed...
    7. Hsieh CH, Kuo SW, Pei D, Hung YJ, Chyi_Fan S, Wu LI, He CT, Yang TC, Lian WC, Chien-Hsing L. Thyrotoxic periodic paralysis: an overwiew. Ann Saudi Med 2004; 24: 418-422. Go to original source... Go to PubMed...
    8. Pouget J, Philip N, Fauguere G, Pellisier JF. Andersen syndrome - a particular form of paralysis with cardiac dysrythmia. Rev Neurol (Paris) 2004; 160: S38-42. Go to original source... Go to PubMed...
    9. Ptacek L. The familial periodic paralyses and nondystrophic myotonias. Am J Med 1998; 105: 58-70. Go to original source... Go to PubMed...
    10. Ryan MM, Taylor P, Donald JA, et al. A novel syndrome of episodic muscle weakness maps to xp 22.3. Am J Hum Genet 1999; 65: 1104-1113. Go to original source... Go to PubMed...
    11. Tassone H, Moulin A, Henderson SO. The pitfalls of potassium replacement in thyrotoxic periodic paralysis: a case report and review of the literature. J Emerg Med 2004; 26: 157-161. Go to original source... Go to PubMed...
    12. Tyler FH, Stephens FD, Perkoff GT. Clinical manifestations and inheritance of a type of periodic paralysis without hypopotassemia. J Clin Invest 1951; 30: 492-502. Go to original source... Go to PubMed...
    13. www.neuro.wustl.edu/neuromuscular/mtime/mepisodic.html

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.