Neurol. praxi. 2009;10(2):80-82

Neuropsychobiology of suicide

prof. MUDr. Peter Kukumberg Ph.D

II. neurologická klinika LF UK FNsP akademika L. Dérera v Bratislave

Suicide is a fatal act of ultra-extreme judgement, determination, and conduct. It appears as a destructive antipole of the instinct

of self-preservation or as a terrifying self-execution of an individual being one‘s own judge, advocate, and executioner. In causal and

empirical terms, it most commonly occurs with a depressive disorder, schizophrenia, decompensated abuse, conditions following spinal

cord trauma, multiple sclerosis, Parkinson‘s disease, Huntington‘s disease, and epilepsy. It does not occur among animals. There is

no systemic prevention. Numerous but inconclusive findings (mostly post mortem) indicate that neurotransmitters (serotonin, dopamine,

GABA, etc.) and/or other substances in the blood, cerebrospinal fluid, tissue, and urine are involved in suicidal behaviour and action.

There is no clear evidence of a genetic deviation. No suicidal markers have been established. Suicide represents an extremely serious

sociological-medical problem with poor prevention and is among the five leading causes of death.

Keywords: suicide, suicide definitions, suicide prevention, sociological-medical phenomenon of suicide, neurotransmitters, depressive disorder, Parkinson‘s disease, Huntington‘s disease, multiple sclerosis, epilepsy.

Published: May 1, 2009  Show citation