Neurol. praxi. 2010;11(2):95-99
Pharmacotherapy of myastenia gravis
- Neurologická klinika LF MU a FN, Brno
Therapy of myasthenia gravis is based on two parts: symptomatic and disease modifying procedures. Among cholinestrase inhibitors
(symptomatic therapy) pyridostigmine is widely used. This medication is administered in patients with the ocular or very mild form of
myasthenia. In other patients immunosuppressive medication should be introduced. The key role plays prednisone and/or other steroid
sparing drugs as azathioprine, cyclosporine, or mycophenolate mophetil. Plasma exchange or intravenous immunoglobulin is indicated
in patients with myasthenic crisis or other severe resistant symptoms.
Keywords: myasthenia, therapy, immunoglobulin, plasmapheresis
Published: April 1, 2010 Show citation
References
- Batocchi AP, Evoli A, Di Schino C, Tonali P. Therapeutic Apheresis in Myasthenia Gravis. Ther Apher 2000; 4: 275-279.
Go to original source... 
Go to PubMed... - Christensen PB, Jensen TS, Tsiropoulos I, S?rensen T, Kjaer M, H?jer-Pedersen E, Rasmussen MJK, Lehfeldt E. Mortality and survival in myasthenia gravis: a Danish population based study. J Neurol Neurosurg Psychiatry 1998; 64: 78-83. Go to original source... Go to PubMed...
- Díaz-Manera J, Rojas-García R, Illa I. Treatment strategies for myasthenia gravis. Expert Opin Pharmacother 2009; 10: 1329-1342. Go to original source... Go to PubMed...
- Drachman DB, Adams RN, Hu R, Jones RJ, Brodsky RA. Rebooting the immune system with high-dose cyclophosphamide for treatment of refractory myasthenia gravis. Ann NY Acad Sci 2008; 1132: 305-314. Go to original source... Go to PubMed...
- Gajdos P, Chevret S, Toyka K. Plasma exchange for myasthenia gravis (Review) 2009 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd. The Cochrane Library 2009, Issue 2. Dostupné na http://www.thecochranelibrary.com.
- Juel VC. Myasthenia gravis: management of myasthenic crisis and perioperative care. Semin Neurol 2004; 24: 75-81. Go to original source... Go to PubMed...
- Lebrun C, Bourg V, Tieulie N, Thomas P. Successful treatment of refractory generalized myasthenia gravis with rituximab. Eur J Neurol 2009; 16: 246-250. Go to original source... Go to PubMed...
- Nelson RP Jr, Pascuzzi RM, Kessler K, Walsh LE, Faught PP, Ramanuja S, Pescovitz MD, Loehrer PJ Sr. Rituximab for the treatment of thymoma-associated and de novo myasthenia gravis: 3 cases and review. J Clin Neuromuscul Dis 2009; 10: 170-177. Go to original source... Go to PubMed...
- Monsul NT, Patwa HS, Knorr AM, Lesser RL, Goldstein JM. The effect of prednisone on the progression from ocular to generalized myasthenia gravis. J Neurol Sci 2004; 217: 131-133. Go to original source... Go to PubMed...
- Sathasivam S. Steroids and immunosuppressant druha in myastenia gravis. Nat Clin Pract 2008; 4: 317-327. Go to original source... Go to PubMed...
- Shibuya N, Sato T, Osame M, Raketami T, Doi S, Kawanami S. Immunoadsorption therapy for myasthenia gravis. J Neurol Neurosurg Psychiatry 1994; 57: 578-658. Go to original source... Go to PubMed...
- Skeie GO, Apostolski S, Evoli A, Gilhus NE, Hart IK, Harms L, Hilton-Jones D, Melms A, Verschuuren J, Horge HW. Guidelines for the treatment of autoimmune neuromuscular transmission Disorders. Eur J Neurol 2006; 13: 691-699. Go to original source... Go to PubMed...
- Strober J, Cowan MJ, Horn BN. Allogeneic hematopoietic cell transplantation for refractory myasthenia gravis. Arch Neurol 2009; 66: 659-661. Go to original source... Go to PubMed...
- Witte AS, Cornblath DR, Parry GJ, Lisak RP, Schatz NJ. Azathioprine in the treatment of myasthenia gravis. Ann Neurol 1984; 15: 602-605. Go to original source... Go to PubMed...