Neurol. praxi. 2010;11(2):129-132
Primary brain lymphoma
- 1 Neurologická klinika, Pardubická krajská nemocnice, Pardubice
- 2 Patologie Litomyšl
- 3 Radiodiagnostické oddělení, Pardubická krajská nemocnice, Pardubice
Primary central nervous system lymphoma (PCNSL) makes 1–2 % of all primary cerebral tumors. In contrast to lymphomas arising from
nodal lymphatic tissues, PCNSL affect cerebral tissue. These tumors belong to a variety of non-Hodgkin lymphomas. Their occurrence
is especially in immunocompromised patients. PCNSL is in principle good curable with chemotherapy and radiotherapy. The tumor
sometimes does not show on follow-up imaging examination after intensive immunosuppressive therapy. Therefore, this tumor is also
marked as a vanishing tumor. The diagnosis of PCNSL is verified by the immunohistochemical examinations which certify lymphoid
tumor cells. If there are doubts between histological and imaging examination, problems will appear. These problems complicate the
course of this disease. We treated a patient with this complicated course of disease in our clinic.
Keywords: primary central nervous system lymphoma, non-Hodgkin lymphoma, corticotherapy, brain biopsy, chemotherapy, radiotherapy
Published: April 1, 2010 Show citation
References
- Bhagavathi S, Wilson JD. Primary central nervous system lymphoma. Arch Pathol Lab Med. 2008; 132: 1830-1834.
Go to original source... - Correa DD, Maron L, Hardet H, Klein M, Armstrong CL, Calabrese P, Bromberg JEC, Abrey LE, Batchelor TT, Schiff D. Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines. Ann Oncol 2007; 18: 1145-1151. Go to original source...
Go to PubMed... - Fliessbach K, Urbach H, Helmstaedter C, Pels H, Glasmacher A, Kraus J, Klockgether T, Schmidt-Wolf I, Schlegel U. Cognitive performance and magnetic resonance imaging findings after high-dose systematic and intraventricular chemotherapy for primary central nervous system lymphoma. Arch Neurol. 2003; 60: 563-568. Go to original source... Go to PubMed...
- Ichikawa Y, Maeda M, Ishida M, Takeda K, Hirano T. Unusual MRI findings in primary central nervous system lymphoma presenting diffuse linear enhancements located in the perivascular space. J Neurol 2006; 256: 1094-1096. Go to original source... Go to PubMed...
- Kanai R, Shibuya M, Hata T, Hori M, Hirabayashi K, Terada T, Fujii K. A case of Lymphomatosis cerebri diagnose in an early phase and treated by whole brain radiation: case report and literature review. J Neurooncol 2008; 86: 83-88. Go to original source... Go to PubMed...
- Krč I, Mačák J, Urbánek K, Galuszkova D, Juryšek O. Primární extranodální non-Hodgkinovy lymfomy I. Interní Med. 1999; 5: 26-29.
- Küker W, Nägele T, Korfel A, Heckl S, Thiel E, Bamberg M, Weller M, Herrlinger U. Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. J Neurooncol 2005; 72: 169-177. Go to original source... Go to PubMed...
- Morris PG, Abrey LE. Therapeutic challenges in primary CNS Lymphoma. Lancet Neurol 2009; 8: 581-592. Go to original source... Go to PubMed...
- Omuro MP, Ben-Porat LS, Panageas KS, Kim AK, Correa DD, Yahalom J, De Angelis LM, Abrey LE. Delayed neurotoxicity in primary central nervous system lymphoma. Arch Neurol 2005; 62: 1595-1600. Go to original source... Go to PubMed...
- Paul TR, Challa S, Tandon A, Panigrahi MK, Purohit AK. Primary central nervous system lymphomas: Indian experience, and review of literature. Ind J Canc 2008; 45: 3. Go to original source... Go to PubMed...
- Plotkin SR, Batchelor TT. Primary nervous-system lymphoma. Lancet Oncol 2001; 2: 354-365. Go to original source... Go to PubMed...
- Ghesqui?res H, Ferlay C, Sebban C, Perol D, Bosly A, Casasnovas O, Reman O, Coiffier B, Tilly H, Morel P, Van den Neste E, Colin P, Haioun C, Biron P, Blay JY. Long-term follow-up of an age-adapted C5R protocol followed by radiotherapy in 99 newly diagnosed primary CNS lymphomas: a prospective multicentric phase II study of the Groupe d'Etude des Lymphomes de l'Adulte (GELA). Ann Oncol. 2009 Nov 18. [Epub ahead of print]). Go to original source... Go to PubMed...