Neurol. praxi. 2011;12(3):175-180

Alzheimer’s disease and mild cognitive impairment: diagnosis and treatment

MUDr.Linda Čechová¹, doc.MUDr.Aleš Bartoš, Ph.D.^1,2, MUDr.David Doležil, Ph.D.¹, RNDr.Daniela Řípová, CSc.²

¹ Univerzita Karlova v Praze, 3. LF, FN KV, Neurologická klinika, Praha

² AD Centrum, Psychiatrické centrum Praha

Early recognition of the dementia syndrome is the most important part in the diagnostics of Alzheimer‘s disease. It is followed by determination

of Alzheimer‘s disease as the most likely cause of it. A clinical transitional state between the normal ageing and dementia is

referred to as mild cognitive impairment. The auxiliary diagnostic methods are not only used to rule out other causes of dementia, but

they can directly support the diagnosis of Alzheimer‘s disease. The clinical trials have proved that current drugs slow the progression of

the disease. We can use acetylcholinesterase inhibitors for treatment of mild to moderate Alzheimer‘s disease, whereas severe stages

of the disease are treated by memantin – NMDA receptor partial antagonist.

Keywords: Alzheimer‘s disease, mild cognitive impairment, dementia, diagnostics, biomarkers, therapy

Published: June 1, 2011  Show citation