Neurol. praxi. 2011;12(4):277-281

New guidelines for diagnosis and therapy of Alzheimer´s disease

doc.MUDr.Jakub Hort, Ph.D.^1,2

¹ Neurologická klinika UK, 2. LF a FN Motol, Praha

² Mezinárodní centrum klinického výzkumu, FN u sv. Anny, Brno

Guidelines for diagnosis and therapy of Alzheimer´s disease provides an evidence based review of the literature. Scientific papers are

assessed according to levels of evidence, where I means the most convincing and IV means the weakest evidence. There was provided

a recommendation of level A – efficient, B – probably efficient and C – possibly efficient, based on the levels of evidence. Presented

guidelines revise previous recommendations published in 2007. New biomarkers of Alzheimer´s disease are discussed, especially examination

of cerebrospinal fluid, magnetic resonance and other imaging methods, as well as new neuropsychological instruments. In

the pharmacological section, there are critically evaluated many substances lacking sufficient evidence of its efficacy, but still used in

the Czech Republic.

Keywords: guidelines, evidence based medicine, Alzheimer´s disease, diagnosis, management

Published: July 29, 2011  Show citation