Neurol. praxi. 2012;13(2):105-108

Alzheimer’s disease and type 2 diabetes mellitus

doc.MUDr.Miroslav Zeman, CSc.1, doc.MUDr.Roman Jirák, CSc.2
1 IV. interní klinika 1. LF UK a VFN Praha
2 Psychiatrická klinika 1. LF UK a VFN Praha

Both the epidemiological data and results of experimental works have shown tight relations of the insulin resistance, type 2 diabetes

mellitus (DM2), cognitive disturbances and sporadic form of Alzheimer´s disease. Plethora of events, standing behind these relations, is

associated with an abnormal brain glucose metabolism. Some authors call Alzheimer‘s disease, „type 3 diabetes mellitus“. In the article,

an outline is given on the mechanisms, connecting both the insulin resistance and DM2 with the cognitive disturbances or dementia.

Some new potential possibilities of the favourable influencing of the sporadic form of Alzheimer´s disease are also mentioned. The

research in the field could help to find new biological markers of the Alzheimer´s disease, recognition of the new treatment targets and

of new preventive and treatment modalities of this serious disorder.

Keywords: sporadic form of Alzheimer´s disease, type 2 diabetes mellitus, insulin resistance

Published: April 23, 2012  Show citation

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Zeman M, Jirák R. Alzheimer’s disease and type 2 diabetes mellitus. Neurol. praxi. 2012;13(2):105-108.
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