Neurol. praxi. 2012;13(4):225-228

Forgetfulness and walking difficulties with a surprising conclusion

MUDr.Robert Rusina, Ph.D.¹, Mgr.Silvie Johanidesová¹, doc.MUDr.Iva Holmerová, Ph.D.², MUDr.Martin Mašek³, MUDr.Radoslav Matěj, Ph.D.⁴

¹ Neurologická klinika IPVZ a Thomayerova nemocnice, Praha

² CELLO-ILC-CZ, Fakulta humanitních studií UK, Praha

³ Radiodiagnostická klinika 1. LF UK a Nemocnice Bulovka, Praha

⁴ Oddělení patologie a molekulární medicíny, Thomayerova nemocnice, Praha

We report a case of rapidly progressive dementia and Parkinsonism; the clinical diagnosis concluded to mixed dementia (Alzheimer’s disease

and vascular dementia). Neuropathologic findings, however, showed surprisingly a diffuse anaplastic astrocytoma with areas of

glioblastoma. We discuss the principal atypical clinical features in our patient and suggest possible reasons that might have been involved

into the discrepancies between clinical conclusions and the definite histopathological diagnosis. Our observation underlines the

need for confrontations of clinical signs and neuroimaging findings and strengthens the importance of neuropathological verification

of clinical diagnoses in receiving valuable feedback and lessons for the future.

Keywords: Alzheimer’s disease, dementia, glioblastoma, neuroimaging

Published: July 31, 2012  Show citation