Neurol. praxi. 2013;14(4):188-192

What are the risks associated with vaccination in patients with multiple sclerosis? Myths and Reality

MUDr.Jiří Piťha1,2, prof.MUDr.Roman Prymula, CSc., Ph.D.3
1 MS centrum při Neurologickém oddělení KZ a. s. &ndash, Nemocnice Teplice o. z.
2 Neurologická klinika 1. LF UK a VFN Praha, Centrum klinických neurověd
3 Fakultní nemocnice Hradec Králové

Infection is one of the most common factors that lead to exacerbation of multiple sclerosis. Ebstein Barr Virus is even suspected infectious

agents involved in the pathogenesis of the disease. The clinical experience suggests that patients with multiple sclerosis is not recommended

any vaccination for fear of worsening disease. An analysis of clinical studies, it is clear that the majority of vaccines is safe and may even risk

groups to protect patients from infection. For 0.5% of the vaccinees may develop autoimmune/inflammatory syndrome induced adjuvant.

Keywords: multiple sclerosis, infections, vaccination, vaccines

Published: October 1, 2013  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Piťha J, Prymula R. What are the risks associated with vaccination in patients with multiple sclerosis? Myths and Reality. Neurol. praxi. 2013;14(4):188-192.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Ahlgren C, Torén K, Odén A, Andersen O. A population-based case-control study on viral infections and vaccinations and subsequent multiple sclerosis risk. Eur J Epidemiol. 2009; 24: 541-552. Go to original source... Go to PubMed...
    2. Andersen O, Lynger PE, Bergstrom T, Anderson M, Vahlne A. Viral infection trigger multiple sclerosis relapses: a prospektive epidemiological study. J Neurol. 1993; 240: 417-422. Go to original source... Go to PubMed...
    3. Auriel E, Gadoth A, Regev K, Karni A. Seasonal and H1N1v influenza vaccines in MS: safety and compliance. J Neurol Sci. 2012; 314: 102-103. Go to original source... Go to PubMed...
    4. Baumhackl U, Franta C, Retzl J, Salomonowitz E, Eder G. A controlled trial of tick-borne encephalitis vaccination in patients with multiple sclerosis. Vaccine. 2003; Suppl 1: S56-S61. Go to original source... Go to PubMed...
    5. Cerpa-Cruz S, Paredes-Casillas P, Landeros Navarro E, Bernard-Medina AG, Martínez-Bonilla G, Gutiérrez-Ure?a S. Adverze events following immunization with vaccines containing adjuvants. Immunol Res. 2013; 56: 357-363. Go to original source... Go to PubMed...
    6. Confavreux C, Suissa S, Saddier P, Bourdes V, Vukusic S. Vaccinations and the risk of relapse in multiple sclerosis. N Engl J Med. 2001; 344: 319-326. Go to original source... Go to PubMed...
    7. De Keyser J, Zwanikken C, Boon M. Effects of influenza vaccination and influenza illness on exacerbations in multiple sclerosis. J Neurol Sci. 1998; 159: 51-53. Go to original source... Go to PubMed...
    8. Edwards S, Zvartau M, Clarke H, Irving W, Blumhardt LD. Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1998; 64: 736-741. Go to original source... Go to PubMed...
    9. Farez MF, Correale J. Yellow fever vaccination and increased relapse rate in travelers with multiple sclerosis. Arch Neurol. 2011; 68: 1267-1271. Go to original source... Go to PubMed...
    10. Farez MF, Correale J. Immunizations and risk of multiple sclerosis: systematic review and meta-analysis. J Neurol. 2011; 258: 1197-1206. Go to original source... Go to PubMed...
    11. Gay D, Dick G, Upton G. Multiple sclerosis associated with sinusitis: case-controlled study in general practice. Lancet. 1986; 1: 815-819. Go to original source... Go to PubMed...
    12. Hernán MA, Jick SS, Olek MJ, Jick H. Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective study. Neurology. 2004;63: 838-842. Go to original source... Go to PubMed...
    13. Isai A, Durand J, Le Meur S, Hidalgo-Simon A, Kurz X. Autoimmune disorders after immunisation with Influenza A/H1N1 vaccines with and without adjuvant: EudraVigilance data and literature review. Vaccine. 2012; 30: 7123-7129. Go to original source... Go to PubMed...
    14. Kim W, Kim SH, Huh SY, Kong SY, Choi YJ, Cheong HJ, Kim HJ. Reduced antibody formation after influenza vaccination in patients with neuromyelitis optica spectrum disorder treated with rituximab. Eur J Neurol. 2013; 20: 975-980. Go to original source... Go to PubMed...
    15. Loebermann M, Winkelmann A, Hartung HP, Hengel H, Reisinger EC, Zettl UK. Vaccination against infection in patients with multiple sclerosis. Nat Rev Neurol. 2012 24; 8: 143-151. Go to original source... Go to PubMed...
    16. Loebermann M, Boršo D, Hilgendorf I, Fritzsche C, Zettl UK, Reisinger EC. Immunization in the adult immunocompromised host. Autoimmun Rev. 2012; 11: 212-218. Go to original source... Go to PubMed...
    17. Lucas RM, Hughes AM, Lay ML, Ponsonby AL, Dwyer DE, Taylor BV, Pender MP. Ebstein Barr virus and multiple sclerosis. J Neurol Neurosurg Psychiatry. 2011; 82: 1142-1148. Go to original source... Go to PubMed...
    18. Miller H, Cendrowski W, Shapira K. Multiple sclerosis and vaccination. BMJ. 1967; 2: 210-213. Go to original source... Go to PubMed...
    19. Narod S, Johnson-Lussenburg CM, Zheng Q, Nelson R. Clinical viral infections and multiple sclerosis. Lancet 1985; ii: 165-166. Go to original source...
    20. Gay D, Dick G, Upton G. Multiple sclerosis associated with sinusitis: case-controlled study in general practice. Lancet 1986; 1: 815-819. Go to original source... Go to PubMed...
    21. Oikonen M, Laaksonen M, Aalto V, Ilonen J, Salonen R, Erälinna JP, Panelius M, Salmi A. Temporal relationship between environmental influenza A and Epstein-Barr viral infections and high multiple sclerosis relapse occurence. Mult Scler. 2011; 17: 672-80. Go to original source... Go to PubMed...
    22. Ono F. Possible relation of small pox vaccination to multiple sclerosis-like disease. A personal note. Med Hypotheses. 1986; 20: 339-340. Go to original source... Go to PubMed...
    23. Panitch HS. Influence of infection on exacerbations of multiple sclerosis. Ann Neurol. 1994; 36: S24-S28. Go to original source... Go to PubMed...
    24. Riikonen R. The role of infection and vaccination in the genesis of optic neuritis and multiplle sclerosis in chidren. Acta Neurol Scand 1989; 80: 425-431. Go to original source... Go to PubMed...
    25. Ristori G, Buzzi MG, Sabatini U, et al. Use of Bacille Calmette-Guerin (BCG) in multiple sclerosis. Neurology. 1999; 53: 1588-1589. Go to original source... Go to PubMed...
    26. Ross RT, Nicolle LE, Cheang M. The varicella zoster virus: a pilot trial of a potential therapeutic agent in multiple sclerosis. J Clin Epidemiol. 1997; 50: 63-68. Go to original source... Go to PubMed...
    27. Rutschmann OT, McCrory DC, Matchar DB and Immunization Panel of the Multiple Sclerosis Council for Cinical Guidelines. Neurology 2002; 59: 1837-1843.
    28. Shoenfeld Y, Agmon-Levin N., ,ASIA" - Autoimmune/ inflammatory syndrome induced by adjuvants. J Autoimmun 2011; 36: 4-8. Go to original source... Go to PubMed...
    29. Sibley WA, Bamford CR, Clark K. Clinical viral infections and multiple sclerosis. Lancet 1985,1: 1313-1315. Go to original source... Go to PubMed...
    30. Sutton I, Lahoria R, Tan I, Clouston P, Barnett M. CNS demyelination and quadrivalent HPV vaccination. Mult Scler. 2009; 15: 116-119. Go to original source... Go to PubMed...

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.