Neurol. praxi. 2015;16(5):299-301

Fulminant course of lamotrigine-induced toxic epidermal necrolysis

MUDr. Břetislav Lipový, Ph.D.1,2, MUDr. Hana Řihová1, MUDr. Tomáš Kempný, Ph.D.1, MUDr. Ivan Suchánek1
1 Klinika popálenin a rekonstrukční chirurgie FN Brno
2 Lékařská fakulta Masarykovy Univerzity Brno

Toxic epidermal necrolysis (TEN) is a critical exfoliation syndrome that, due to its local nature, mimics superficial burns. It is a drug-induced reaction that is manifested not only on the skin, but also on the mucosae. The induction of an apoptotic process in the dermo-epidermal junction zone is the underlying cause of the disease. Antiepileptics currently represent one of the most important drug groups with respect to developing TEN. The case report presents a young woman who developed toxic epidermal necrolysis following lamotrigine treatment.

Keywords: toxic epidermal necrolysis, lamotrigine

Published: October 1, 2015  Show citation

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Lipový B, Řihová H, Kempný T, Suchánek I. Fulminant course of lamotrigine-induced toxic epidermal necrolysis. Neurol. praxi. 2015;16(5):299-301.
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