Neurol. praxi. 2017;18(2):134-136 | DOI: 10.36290/neu.2017.002

Coincidence of corticobasal syndrome and cerebellar form of multiple system atrophy

MUDr. Michal Minár, PhD.¹, MUDr. Zuzana Košutzká¹, MUDr. Peter Matejička¹, MUDr. Igor Straka¹, prof. MUDr. Peter Valkovič, PhD.^{1, 2}

1II. neurologická klinika LFUK a UNB, Bratislava, 2Ústav normálnej a patologickej fyziológie Slovenskej akadémie vied, Bratislava

The article presents case reports of two patients with an atypical presentation of two distinct neurodegenerative diseases. After 60 years of age, both the patients gradually developed signs of corticobasal syndrome, which included levodopa-resistant, markedly asymmetrical akinetic-rigid parkinsonism with dystonia, myoclonia, and focal cortical deficit. In addition, these patients had cerebellar syndrome with an MRI finding of cerebellar and pontine atrophy, with progressive development of vegetative dysfunction. Based on the clinical presentation and imaging studies, a rare coincidence of corticobasal syndrome and the cerebellar form of multiple system atrophy has been assumed.

Keywords: corticobasal syndrome, multiple system atrophy, cerebellar syndrome, neurodegeneration

Received: March 1, 2017; Accepted: March 6, 2017; Published: May 1, 2017  Show citation