Neurol. praxi. 2021;22(2):158-160

Cerebellar ataxia and stiff person syndrome in patient with anti-GAD antibodies

MUDr. Zuzana Dean1, MUDr. Branislav Veselý, PhD.2
1 Neurologické oddelenie, Nemocnica Levice, s. r. o., Levice
2 Neurologická klinika, Fakultná nemocnica Nitra

Anti-GAD-antibody-associated neurological conditions are typically seen in young or middle-aged females and are often associated with other autoimmune disorders. We report a patient with anti-GAD associated ataxia, in whom symptoms of stiff person syndrome (SPS) as well as diabetes mellitus type 1 (IDDM) and hypothyroidism followed 2.5 years after diagnosis.

Keywords: cerebellar ataxia, stiff person syndrome, glutamic acid decarboxylase antibodies, anti-GAD antibodies.

Received: June 5, 2020; Revised: August 5, 2020; Accepted: August 5, 2020; Prepublished online: August 5, 2020; Published: April 30, 2021  Show citation

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Dean Z, Veselý B. Cerebellar ataxia and stiff person syndrome in patient with anti-GAD antibodies. Neurol. praxi. 2021;22(2):158-160.

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References

  1. Ariño H, Gresa-Arribas N, Blanco Z, Martínez Hernández E, Lidia Sabater L, Petit-Pedrol M, Rouco I, Bataller L, Dalmau JO, Saiz A, Graus F. Cerebellar Ataxia and Glutamic Acid Decarboxylase Antibodies: Immunologic Profile and Long-term Effect of Immunotherapy. JAMA Neurol 2014; 71(8): 1009-101. Go to original source... Go to PubMed...
  2. Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre J-Y, Psimaras D, Alentorn A. Neurological Syndromes Associated with Anti-GAD Antibodies. Int Mol Sci 2020; 21(10): 3701. Go to original source... Go to PubMed...
  3. Degeneffe A, Dagonnier M, D'hondt A, Elosegi JA. A case report of rigidity and recurrent lower limb myoclonus: progressive encephalomyelitis rigidity and myoclonus syndrome, a chameleon. BMC Neurology 2018; 18: 173. Go to original source... Go to PubMed...
  4. Honnorat J, Saiz A, Giometto B, Vincet A, Brieva L, deAndres C, Maestre J, Fabien N, Vighetto A, Casamitjana R, Thivolet Ch, Tavolato B, Antoine J Ch, Trouillas P, Graus F. Cerebellar Ataxia with Anti-Glutamic Acid Decarboxylase Antibodies. Study of 14 Patients. Arch Neurol 2001; 58: 225-230. Go to original source... Go to PubMed...
  5. Markakis I, Alexiou E, Xifaras M, Gekas G, Rombos A. Opsoclonus-myoclonus-ataxia syndrome with autoantibodies to glutamic acid decarboxylase. Clin Neurol Neurosurg 2008; 110: 619-621. Go to original source... Go to PubMed...
  6. Mitoma H, Hadjivassiliou M, Honnorat J. Guidelines for treatment of immune-mediated cerebellar ataxias. Cerebellum & Ataxias 2015; 2: 14. Go to original source... Go to PubMed...
  7. Quintas S, Lopez Ruiz R, Zapata-Wainberg G, Vivancos J. Rapidly Progressing Cerebellar Ataxia Associated with anti-GAD antibodies. Neurologia 2018: 33: 273-275. Go to original source... Go to PubMed...
  8. Seneviratne SO, Buzzard KA, Cruse B, Monif M. Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies. Case Report Imunol 2020; Feb 8. Go to original source... Go to PubMed...




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