Neurol. praxi. 2021;22(6):454-458 | DOI: 10.36290/neu.2021.109

Serum biomarkers in mild traumatic brain injury

MUDr. Martina Martiníková1, MUDr. Róbert Ružinák2, doc. MUDr. Vladimír Donáth, PhD.1, prof. MUDr. Egon Kurča, PhD.2, doc. MUDr. Štefan Sivák, PhD.2
1 II. neurologická klinika SZU, FNsP FDR Banská Bystrica
2 Neurologická klinika UNM a JLF UK Martin

More than 50 million people sustain a traumatic brain injury each year. Recently as a result of increased development of proteomics analysis and other discovery techniques, investigators have reported ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) as novel potential markers for brain injury. Blood-based brain biomarkers hold the potential to predict absence of intracranial injury and thus reduce unnecessary head CT scanning. Blood-based brain biomarkers also hold the potential to document whether a concussion occurred, especially when the history is unclear. For this reason, multi-markers analysis that presents glial and neuronal cell body damage should be performed.

Keywords: mild traumatic brain injury, GFAP, UCH-L1.

Published: December 9, 2021  Show citation

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Martiníková M, Ružinák R, Donáth V, Kurča E, Sivák Š. Serum biomarkers in mild traumatic brain injury. Neurol. praxi. 2021;22(6):454-458. doi: 10.36290/neu.2021.109.
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    References

    1. Babcock L, Zhang N, Leach J, Wade SL. Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury? Brain Inj. 2016; 30(10): 1231-1238. Go to original source... Go to PubMed...
    2. Bazarian JJ, Biberthaler P, Welch RD, Lewis LM, Barzo P, Bogner-Flatz V, Brolinson PG, Buki A, Chen JY, Christenson RH, Hack D, Huff JS, Johar S, Jordan JD, Leidel BA, Linder Tobias, Ludington E, Okonkwo DO, Ornato J, Peacock WF, Schmidt K, Tyndall JA, Vossugh A, Jagoda AS. Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study. Lancet neurology 2018; 17(9): 782-789. Go to original source... Go to PubMed...
    3. Berger RP, Adelson PD, Pierce MC, Dulani T, Cassidy LD, Kochanek PM. Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. J Neurosurg. 2005; 103(1 Suppl): 6-8. Go to original source... Go to PubMed...
    4. Bogoslovsky T, Gill J, Jeromin A, Davis C, Diaz-Arrastia R. Fluid biomarkers of traumatic brain injury and intended context of use. Diagnostics (Basel). 2016; 6(4): pii:E37. Go to original source... Go to PubMed...
    5. Clarke GJB, Skandsen T, Zetterberg H, Einarsen CE, Feyling C, Follestad T, Vik A, Blennow K, Håberg AK. One-Year Prospective Study of Plasma Biomarkers From CNS in Patients With Mild Traumatic Brain Injury. Front Neurol. 2021; 12: 643743. doi: 10.3389/fneur.2021.643743. PMID: 33967940; PMCID: PMC8097004. Go to original source... Go to PubMed...
    6. De Kruijk JR, Leffers P, Menheere PP, Meerhof S, Rutten J, Twijnstra A. Prediction of post-traumatic complaints after mild traumatic brain injury: early symptoms and biochemical markers. J Neurol Neurosurg Psychiatry. 2002; 73: 72-732. Go to original source... Go to PubMed...
    7. Gan ZS, Stein SC, Swanson R, Guan S, Garcia L, Mehta D, Smith DH. Blood biomarkers for traumatic brain injury: a quantitative assessment of diagnostic and prognostic accuracy. Frontiers in neurology 2019; 10: 446. Go to original source... Go to PubMed...
    8. Gatson JW, Barillas J, Hynan LS, Diaz-Arrastia R, Wolf SE. Detection of neurofilament-H in serum as a diagnostic tool to predict injury severity in patients who have suffered mild traumatic brain injury. Journal of neurosurgery 2014; 121(5): 1232-1238. Go to original source... Go to PubMed...
    9. Gill J, Latour L, Diaz-Arrastia R, Motamedi V, Turtzo C, Shahim P, Mondello S, DeVoto C, Veras E, Hanlon D, Song L, Jeromin A. Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI. Neurology. 2018; 91(15): e1385-e1389. Go to original source... Go to PubMed...
    10. Jones A, Jarvis P. Review of the potential use of blood neuro-biomarkers in the diagnosis of mild traumatic brain injury. Clinical and experimental emergency medicine 2017; 4(3). Go to original source... Go to PubMed...
    11. Kawata K, Liu CHY, Merkel SF, Ramirez SH, Tierney RT, Langford D. Blood biomarkers for brain injury: What are we measuring? Neurosci Biobehav Rev. 2016; 68: 460-473. Go to original source... Go to PubMed...
    12. Kou Z, Gattu R, Kobeissy F, Welch RD, O´Neil BJ, Woodard JL, Ayaz SI, Kulek A, Kas-Shamoun R, Mika V, Zuk C, Tomasello F, Mondello S. Combining biochemical and imaging markers to improve diagnosis and characterization of mild traumatic brain injury in the acute setting: results from a pilot study. PloS One 2013; 8(11): e80296. Go to original source... Go to PubMed...
    13. Kulbe JR, Geddes JW. Current status of fluid biomarkers in mild traumatic brain injury. Experimental neurology. 2016; 275(Pt 3): 334-352. Go to original source... Go to PubMed...
    14. Lee JY, Lee CHY, Kim HR, Lee CH, Kim HW, Kim JH. A role of serum-based neuronal and glial markers as potential predictors for distinguishing severity and related outcomes in traumatic brain injury. Journal of Korean Neurosurgical Society 2015; 58(2): 93-100. Go to original source... Go to PubMed...
    15. Mondello S, Sorinola A, Czeiter E, Vámos Z, Amrein K, Synnot A, Donoghue E, Sándor J, Wang K, Diaz-Arrasia R, Steyerberg E, Menon D, Maas A, Buki A. Blood - based protein biomarkers for the management of traumatic brain injuries in adults presenting to emergency departments with mild brain injury: A living systematic review and meta-analysis. Journal of Neurotrauma 2021; 38 (8). Go to original source... Go to PubMed...
    16. Papa L, Akinyi L, Liu MCH, Pineda JA, Tepas JJ, Oli MW, Zheng W, Robinson G, Robicsek SA, Gabrielli A, Heaton SC, Hannay HJ, Demery JA, Brophy GM, Layon J, Robertson CS, Hayes RL, Wang KKW. Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Critical care medicine 2010; 38(1): 138-144. Go to original source... Go to PubMed...
    17. Papa L. Exploring the role of biomarkers for the diagnosis and management of traumatic brain injury patients. In: TSZ KWONG MAN (ed.) Proteomics - Human diseases and protein functions. Shanghai: InTech 2012: 90-106. Go to original source...
    18. Papa L, Lewis LM, Falk JL, Zhang Z, Silvestri S, Giordano P, Brophy GM, Demery JA, Dixit NK, Ferguson I, Liu MCH, Mo J, Akinyi L, Schmid K, Mondello S, Robertson CS, Tortella FC, Hayes RL, Wang KKW. Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Annals of emergency medicine 2012b; 59(6): 471-483. Go to original source... Go to PubMed...
    19. Papa L, Edwards D, Ramia M. Exploring serum biomarkers for mild traumatic brain injury. In: KOBEISSY, FH. Brain neurotrauma: molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton: CRC Press/Taylor & Francis 2015: Chapter 22.
    20. Papa L, Brophy GM, Welch RD, Lewis LM, Braga CF, Tan CN, Ameli NJ, Lopez MA, Haeussler CA, Giordano DIM, Silvestri S, Giordano P, Weber KD, Hill-Pryor C, Hack DC. Time course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic brain injury. JAMA neurology 2016; 73(5): 551-560. Go to original source... Go to PubMed...
    21. Siman R, Giovannone N, Hanten G, Wilde EA, McCauley SR, Hunter JV, Li X, Levin HS, Smith DH. Evidence that the blood biomarker SNTF predicts brain imaging changes and persistent cognitive dysfunction in mild TBI patients. Frontiers in neurology 2013; 4: 190. Go to original source... Go to PubMed...
    22. Siman R, Shahim P, Tegner Y, Blennow K, Zetterberg H, Smith DH. Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Postconcussion Symptoms. J Neurotrauma. 2015; 32(17): 1294-1300. Go to original source... Go to PubMed...
    23. Undén J, Ingebrigtsen T, Romner B; Scandinavian Neurotrauma Committee (SNC). Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update. BMC Med. 2013; 11: 50. Go to original source... Go to PubMed...
    24. U.S. Food and Drug Administration. Evaluation of Automatic Class III Designation for Banyan Brain Trauma Indicator: Decision Memorandum. Silver Spring, MD: U.S. Food and Drug Administration; 2018: 1-32.
    25. Vos PE, Alekseenko Y, Battistin L, Ehler E, Gerstenbrand F, Muresanu DF, Potapov A, Stepan CA, Traubner P, Vecsei L, von Wild K. Mild traumatic brain injury. Eur J Neurol. 2012; 19(2): 191. Go to original source... Go to PubMed...
    26. Zemlan FP, Jauch EC, Mulchahey JJ, Gabbita SP, Rosenberg WS, Speciale SG, Zuccarello M. C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome. Brain Res. 2002; 947(1): 131-9. Go to original source... Go to PubMed...
    27. Zetterberg H, Smith DH, Blennow K. Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nat Rev Neurol. 2013; 9(4): 201-210. doi:10.1038/nrneurol.2013.9. Go to original source... Go to PubMed...
    28. Zhang Z, Zoltewicz S, Mondello S, Newsom KJ, Yang Z, Yang B, Kobeissy F, Guingab J, Glushakova O, Robicsek S, Heaton S, Buki A, Hannay J, Gold MS, Rubenstein R, Lu X, Dave JR, Schmid K, Tortella F, Robertson CS, Wang KKW. Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products. Plos one. 2014; 9(3): e92698. Go to original source... Go to PubMed...

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