Neurol. praxi. 2021;22(6):519-522 | DOI: 10.36290/neu.2021.112
Creutzfeldt-Jakobov disease: clinical case report
- 1 Neurologické oddělení Nemocnice ve Frýdku-Místku
- 2 Národní referenční laboratoř pro diagnostiku lidských TSE/CJD (NRL TSE/CJD) při Oddělení patologie Fakultní Thomayerovy nemocnice, Praha
Sporadic Creutzfeldt-Jacob disease (sCJD) is rare, prion and incurable disease. It is characterized by the rapid development of dementia and other focal symptoms. Typical signs of CJD are found in the MR examination of the brain, in the EEG and in the examination of cerebrospinal fluid. The definitive diagnosis is determined by neuropathological examination of brain tissue. We present the case of an elderly man with sudden onset and rapidly progressing dementia and characteristic findings in auxiliary examination methods. Neuropathological changes in the brain eventually demonstrated changes typical of Creutzfeldt-Jakob disease, but also of frontotemporal lobar degeneration with tau positive inclusions.
Keywords: Creutzfeldt-Jacob disease, dementia, prion diseases.
Published: December 9, 2021 Show citation
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