Neurol. praxi. 2023;24(4):310-313 | DOI: 10.36290/neu.2023.014

Progressive multifocal leukoencephalopathy as a primary opportunistic infection in a patient with AIDS

MUDr. Martina Miklušová, MUDr. Dalibor Zimek
Neurologická klinika LF UP v Olomouci a FN Olomouc

Progressive multifocal leukoencephalopathy is a rare demyelinating disorder of the central nervous system, which is found almost entirely in immunocompromised persons - mostly as late complication of HIV infection. We present a case report of rare situation, in which the diagnosis of PML preceded the diagnosis of long-lasting HIV infection. This patient was also the first patient with this diagnosis in Neurology department of The University Hospital Olomouc.

Keywords: leukoencephalopathy, progressive multifocal, HIV, acquired immunodeficiency syndrome, opportunistic infections.

Received: November 8, 2022; Revised: January 26, 2023; Accepted: March 7, 2023; Prepublished online: March 7, 2023; Published: September 8, 2023  Show citation

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Miklušová M, Zimek D. Progressive multifocal leukoencephalopathy as a primary opportunistic infection in a patient with AIDS. Neurol. praxi. 2023;24(4):310-313. doi: 10.36290/neu.2023.014.
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References

  1. Alstadhaug KB, Myhr K­‑M, Rinaldo CH. Progressive multifocal leukoencephalopathy. Tidsskr Den Nor Legeforening. 2017;10. DOI: 10.4045/tidsskr.16.1092. Go to original source... Go to PubMed...
  2. Bartsch T, Rempe T, Leypoldt F, et al. The spectrum of progressive multifocal leukoencephalopathy: a practical approach. Eur J Neurol. 2019;26:566-e41. doi:10.1111/ene.13906. Go to original source... Go to PubMed...
  3. Bellizzi A, Anzivino E, Rodio DM, et al. New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy. Clin Dev Immunol. 2013;2013:1-17. doi:10.1155/2013/839719. Go to original source... Go to PubMed...
  4. Berger JR, Aksamit AJ, Clifford DB, et al. PML diagnostic criteria. Neurology. 2013;80:1430-8. doi:10.1212/WNL. 0b013e31828c2fa1. Go to original source... Go to PubMed...
  5. Cortese I, Reich DS, Nath A. Progressive multifocal leukoencephalopathy and the spectrum of JC virus­‑related disease. Nat Rev Neurol. 2021;17:37-51. doi:10.1038/s41582-020-00427-y. Go to original source... Go to PubMed...
  6. Engsig FN, Hansen A­‑BE, Omland LH, et al. Incidence, Clinical Presentation, and Outcome of Progressive Multifocal Leukoencephalopathy in HIV­‑Infected Patients during the Highly Active Antiretroviral Therapy Era: A Nationwide Cohort Study. J Infect, DiS. 2009;199:77-83. doi:10.1086/595299. Go to original source... Go to PubMed...
  7. HIV. World Health Organization (WHO) [online]. Copyright © [cit. 26. 01. 2023]. Available from: https://www.who.int/data/gho/data/themes/hiv­‑aids
  8. Harypursat V, Zhou Y, Tang S, et al. JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review. AIDS Res Ther. 2020;17:37. doi:10.1186/s12981-020-00293-0. Go to original source... Go to PubMed...
  9. Khanna N, Elzi L, Mueller NJ, et al. Incidence and Outcome of Progressive Multifocal Leukoencephalopathy over 20 Years of the Swiss HIV Cohort Study. Clin Infect, DiS. 2009;48:1459-66. doi:10.1086/598335. Go to original source... Go to PubMed...
  10. Maas RPPWM, Muller­‑Hansma AHG, Esselink RAJ, et al. Drug­‑associated progressive multifocal leukoencephalopathy: a clinical, radiological, and cerebrospinal fluid analysis of 326 cases. J Neurol. 2016;263:2004-21. doi:10.1007/s00415-016-8217-x. Go to original source... Go to PubMed...
  11. Progressive Multifocal Leukoencephalopathy - National Organization for Rare Disorders. National Organization for Rare Disorders | NORD [online]. Copyright © 2023 NORD [cit. 26. 01. 2023]. Available from: https://rarediseases.org/rare­‑diseases/progressive­‑multifocal­‑leukoencephalopathy/?filter=ovr­‑ds­‑resources.
  12. Rozsypal H. Oportunní infekce centrálního nervového systému u osob infikovaných lidským virem insuficience. Neurol. praxi. 2021;22(4):278-282. Go to original source...
  13. Sahraian MA, Radue E­‑W, Eshaghi A, et al. Progressive multifocal leukoencephalopathy: a review of the neuroimaging features and differential diagnosis. Eur J Neurol. 2012;19:1060-9. doi:10.1111/j.1468-1331.2011.03597.x. Go to original source... Go to PubMed...
  14. Sarbu N, Shih RY, Oleaga L, et al. RadioGraphics Update: White Matter Diseases with Radiologic­‑Pathologic Correlation. RadioGraphics. 2020;40:E4-7. doi:10.1148/rg.2020190204. Go to original source... Go to PubMed...




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