Neurol. praxi. 2023;24(5):346-352 | DOI: 10.36290/neu.2023.050

Precision neuro-oncology: reality and perspectives

Ing. et Ing. Jiří Polívka, Ph.D.¹, MSc. Rashmi Negi¹, MUDr. Richard Koleják², MUDr. Jiří Polívka, CSc.³, MUDr. Pavel Potužník, Ph.D.³

¹ Ústav histologie a embryologie a Biomedicínské centrum, Lékařská fakulta v Plzni, Univerzita Karlova

² Neurochirurgická klinika, Fakultní nemocnice Plzeň

³ Neurologická klinika, Fakultní nemocnice Plzeň a Lékařská fakulta v Plzni, Univerzita Karlova

Precision oncology represents a new concept of cancer care that allows the best possible individualization of treatment for a particular patient and a particular tumour. This is achieved by using the results of advanced molecular-genetic diagnostic methods which enable detailed tumour molecular profiling and identification of potential targets of modern anticancer treatment, i.e. targeted therapy. The present article deals with gradual changes in the classification of central nervous system tumours which were necessary given the enormous development of knowledge on molecular mechanisms of oncogenesis in recent years. Also included are some important examples of using precision oncology approaches in central nervous system tumours, with a detailed focus on diffuse gliomas.

Keywords: primary CNS tumours, molecular-genetic biomarkers, CNS tumour classification, diffuse gliomas, integrated diagnostics, precision oncology, neuro-oncology.

Received: June 20, 2023; Revised: July 13, 2023; Accepted: July 14, 2023; Prepublished online: July 14, 2023; Published: October 30, 2023  Show citation