Neurol. praxi. 2024;25(6):450-453 | DOI: 10.36290/neu.2024.057

Sleep disorders and stroke

doc. MUDr. Pavel Šiarnik, PhD.1, MUDr. Michal Poddaný2, prof. MUDr. Branislav Kollár, PhD.1
1 I. neurologická klinika Lekárskej fakulty Univerzity Komenského a Univerzitnej nemocnice, Bratislava
2 Neurologické oddelenie, Liptovská nemocnica s poliklinikou MUDr. Ivana Stodolu, Liptovský Mikuláš

Sleep disorders represent a common comorbidity in patients with stroke. Their relationships are complex and bidirectional. Sleep disorders can act as a risk factor for the development of stroke. On the other hand, lesions in the central nervous system can lead to sleep disturbances. Sleep disorders and their treatment can significantly modify the recovery process of the patient and also affect the risk of stroke recurrence. In the following text, we present the mentioned topic. We focus not only on the well-studied sleep apnea but also explain the role of sleep-related movement disorders and insomnia. The interactions of stroke with hypersomnias, circadian rhythm disorders, and parasomnias will need to be more thoroughly investigated by future prospective studies.

Keywords: stroke, sleep-related breathing disorders, insomnia disorders, central disorders of hypersomnolence, circadian rhythm sleep-wake disorders, sleep-related movement disorders, parasomnias.

Received: July 10, 2024; Revised: August 28, 2024; Accepted: August 29, 2024; Prepublished online: August 29, 2024; Published: December 31, 2024  Show citation

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Šiarnik P, Poddaný M, Kollár B. Sleep disorders and stroke. Neurol. praxi. 2024;25(6):450-453. doi: 10.36290/neu.2024.057.
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References

  1. American Academy of Sleep Medicine. International Classification of Sleep Disorders, 3rd ed. Darien: American Academy of Sleep Medicine. 2014: 383 s.
  2. Arnardottir ES, Mackiewicz M, Gislason T, et al. Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep. 2009;32:447-470. doi: 410.1093/sleep/1032.1094.1447. Go to original source... Go to PubMed...
  3. Baillieul S, Dekkers M, Brill AK, et al. Sleep apnoea and ischaemic stroke: current knowledge and future directions. Lancet Neurol. 2022;21:78-88. doi: 10.1016/S1474-4422(1021)00321-00325. Go to original source...
  4. Bassetti C L, Ferini-Strambi L, Brown S, et al. Neurology and psychiatry: waking up to opportunities of sleep: state of the art and clinical/research priorities for the next decade. Eur J Neurol. 2015;22:1337-1354. doi: 1310.1111/ene.12781. Go to original source... Go to PubMed...
  5. Bassetti CLA, Randerath W, Vignatelli L, et al. EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke. Eur J Neurol. 2020;27:1117-1136. doi: 1110.1111/ene.14201. Go to original source... Go to PubMed...
  6. Baylan S, Griffiths S, Grant N, et al. Incidence and prevalence of post-stroke insomnia: a systematic review and meta-analysis. Sleep Med Rev. 2020; 49: 101222. Go to original source... Go to PubMed...
  7. Butt MU, Zakaria M, Hussain HM. Circadian pattern of onset of ischaemic and haemorrhagic strokes, and their relation to sleep/wake cycle. J Pak Med Assoc. 2009;59:129-132.
  8. Duss SB, Seiler A, Schmidt MH, et al. The role of sleep-in recovery following ischemic stroke: a review of human and animal data. Neurobiol Sleep Circadian Rhythms. 2016;2:94-105. 10.1016/j.nbscr.2016.1011.1003. Go to original source... Go to PubMed...
  9. Garcia-Borreguero D, Silber MH, Winkelman JW, et al. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med. 2016;21:1-11. 10.1016/j.sleep.2016.1001.1017. Go to original source... Go to PubMed...
  10. Gottlieb DJ, Somers VK, Punjabi NM, Winkelman JW. Restless legs syndrome and cardiovascular disease: a research roadmap. Sleep Med. 2017;31:10-17. Go to original source... Go to PubMed...
  11. Gottlieb E, Landau E, Baxter H, et al. The bidirectional impact of sleep and circadian rhythm dysfunction in human ischaemic stroke: a systematic review. Sleep Med Rev. 2019;45: 54-69. Go to original source... Go to PubMed...
  12. Hasan F, Gordon C, Wu D, et al. Dynamic Prevalence of Sleep Disorders Following Stroke or Transient Ischemic Attack: Systematic Review and Meta-Analysis. Stroke. 2021;52:655-663. doi: 610.1161/STROKEAHA.1120.029847. Go to original source... Go to PubMed...
  13. He Q, Zhang P, Li G, et al. The association between insomnia symptoms and risk of cardio-cerebral vascular events: A meta-analysis of prospective cohort studies. Eur J Prev Cardiol. 2017;24:1071-1082. Go to original source... Go to PubMed...
  14. Chong PLH, Garic D, Shen MD, et al. Sleep, cerebrospinal fluid, and the glymphatic system: a systematic review. Sleep Med Rev. 2022;61:101572. doi: 10.1016/j.smrv.2021.101572. Go to original source... Go to PubMed...
  15. Jin X, Yang Y, Zhou F, et al. Relationship between long-term shift work; night work; sleep deficiency and stroke: a systematic review and meta-analysis. Sleep Med. 2024;119:499-504. doi: 10.1016/j.sleep.2024.05.031. Go to original source... Go to PubMed...
  16. Katan M, Luft A. Global Burden of Stroke. Semin Neurol. 2018;38:208-211. doi: 210.1055/s-0038-1649503. Go to original source... Go to PubMed...
  17. Katsanos AH, Kosmidou M, Konitsiotis S, et al. Restless legs syndrome and cerebrovascular/cardiovascular events: Systematic review and meta-analysis. Acta Neurol Scand. 2018;137:142-148. doi: 110.1111/ane.12848. Go to original source... Go to PubMed...
  18. Lau HL, Rundek T, Ramos AR. Sleep and Stroke: New Updates on Epidemiology, Pathophysiology, Assessment, and Treatment. Curr Sleep Med Rep. 2019;5:71-82. doi: 10.1007/s40675-40019-00142-40671. Go to original source...
  19. Lin TC, Zeng BY, Chen YW, et al. Cerebrovascular Accident Risk in a Population with Periodic Limb Movements of Sleep: A Preliminary Meta-Analysis. Cerebrovasc Dis. 2018;46:1-9. doi: 10.1159/000490065. Go to original source... Go to PubMed...
  20. Liu J, Wang L N, Ma X, Ji X. Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. Cochrane Database Syst Rev. 2016;10:Cd009622. Go to original source... Go to PubMed...
  21. Luo Y, Yu G, Liu Y, Zhuge C, Zhu Y. Sleep quality after stroke: a systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e33777. doi: 33710.31097/MD.0000000000033777. Go to original source... Go to PubMed...
  22. Manconi M, Fanfulla F, Ferri R, et al. Periodic limb movements during sleep in stroke/TIA: Prevalence, course, and cardiovascular burden. Neurology. 2018;90:e1663-e1672. doi: 1610.1212/WNL.0000000000005471. Go to original source... Go to PubMed...
  23. Montplaisir J, Boucher S, Poirier G, et al. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1997;12:61-65. doi: 10.1002/mds.870120111. Go to original source... Go to PubMed...
  24. Moradiya Y, Janjua N. Presentation and outcomes of "wake-up strokes" in a large randomized stroke trial: analysis of data from the International Stroke Trial. J Stroke Cerebrovasc Dis. 2013;22:e286-292. doi: 210.1016/j.jstrokecerebrovasdis.2012.1007.1016. Go to original source... Go to PubMed...
  25. Ohayon MM, O'hara R, Vitiello MV. Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev. 2012;16:283-295. doi: 210.1016/j.smrv.2011.1005.1002. Go to original source... Go to PubMed...
  26. Petrov ME, Kim Y, Lauderdale D, et al. Longitudinal associations between objective sleep and lipids: the CARDIA study. Sleep. 2013;36:1587-1595. doi: 10.5665/sleep.3104. Go to original source... Go to PubMed...
  27. Pérez-Carbonell L, Bashir S. Narrative review of sleep and stroke. J Thorac Dis. 2020;12:S176-S190. doi: 110.21037/jtd-cus-22020-21002. Go to original source... Go to PubMed...
  28. Riemann D, Espie CA, Altena E, et al. The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023. J Sleep Res. 2023;32:e14035. Go to original source... Go to PubMed...
  29. Scofield H, Roth T, Drake C. Periodic limb movements during sleep: population prevalence, clinical correlates, and racial differences. Sleep. 2008;31:1221-1227.
  30. Šiarnik P, Kollár B. Spánkové apnoe u pacientov s cerebrálnou ischémiou. Neurol. praxi. 2022;23(3):188-191. doi: 10.36290/neu.2022.006. Go to original source...
  31. Toh CH, Siow TY. Glymphatic Dysfunction in Patients With Ischemic Stroke. Front Aging Neurosci. 2021;13:756249. doi: 10.3389/fnagi.2021.756249. Go to original source... Go to PubMed...
  32. Vyas MV, Garg AX, Iansavichus AV, et al. Shift work and vascular events: systematic review and meta-analysis. BMJ. 2012;345:e4800. Go to original source... Go to PubMed...
  33. Wang H, Sun J, Sun M, et al. Relationship of sleep duration with the risk of stroke incidence and stroke mortality: an updated systematic review and dose-response meta-analysis of prospective cohort studies. Sleep Med. 2022;90:267-278. 10.1016/j.sleep.2021.1011.1001. Go to original source... Go to PubMed...
  34. Wang XX, Feng Y, Tan EK, et al. Stroke-related restless legs syndrome: epidemiology, clinical characteristics, and pathophysiology. Sleep Med. 2022;90:238-248. 10.1016/j.sleep.2022.1002.1001. Go to original source... Go to PubMed...




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