Neurol. praxi. 2025;26(5):428 | DOI: 10.36290/neu.2025.053
Paroxysmal blindness in a young patient
- Neurologické oddělení, Masarykova nemocnice v Ústí nad Labem, o. z., Krajská zdravotní, a. s., Ústí nad Labem
Acute blindness is a severe disabling deficit. We report a case of a seventeen-year-old boy who, during a common seasonal infection, developed symptoms of complete amaurosis atypical for its paroxysmal course. The case illustrates the need for a thorough history and the irreplaceability of MRI in neurology. Hyperintense changes of the corpus callosum are a common finding on brain MRI. Cytotoxic lesions of the corpus callosum (CLOCCs) can occur due to a variety of causes ranging from metabolic or infectious ones to trauma, malignancy to autoimmunity, vaccination and others. CLOCCs may be of a transient nature and, in our case, have a good prognosis as well.
Keywords: corpus callosum, blindness, influenza.
Received: May 12, 2025; Revised: June 12, 2025; Accepted: June 12, 2025; Prepublished online: June 12, 2025; Published: November 6, 2025 Show citation
References
- Červinková I, Pavlovská D, Šenkyřík J, et al. Mírná encefalopatie s reverzibilní lézí splenia corporis callosi. Pediatr Praxi. 2020;21(3):200-202.
Go to original source... - Dougherty RF, Ben-Shachar M, Bammer R, et al. Functional organization of human occipital-callosal fiber tracts. Proc Natl Acad Sci USA. 2005;102(20):7350-7355. Go to original source...
Go to PubMed... - Moors S, Makhostin D, Ilchenko D, et al. Cytotoxic Lesions of the Corpus Callosum: A Systematic Review. Eur Radiol. 2024;34(7):4628-4637. Go to original source... Go to PubMed...
- Mračková J, Tupý R. Rohan V, et al. Cytotoxické léze corpus callosum (CLOCCs). Cesk Slov Neurol N. 2020;83/116(4):347-352. Go to original source...
- Shekari S, Farsi F, Ashrafzdeh F, et al. Transient Blindness Due to Mild Reversible Encephalopathy in a 7-Year-Old Boy. Clin Case Rep. 2024;12(2):e8493. Go to original source... Go to PubMed...
- Tetsuka S. Reversible Lesion in the Splenium of the Corpus Callosum. Brain Behav. 2019;9(11):e01440. Go to original source... Go to PubMed...
- Tuscano A, Zoppo M, Canavese C, et al. Transient blindness associated with mild encephalitis/encephalopathy with a reversible splenial lesion (MERS): a case report and review of literature [Internet]. Italian Journal od Pediatrics. 2020 [cited 2025-06-12]. Available from: https://www.springermedicine.com/link?doi=10.1186/s13052-020-00918-0. Go to original source... Go to PubMed...