Neurol. pro Praxi, 2006; 2: 69-71

RNA interferencia – nový nástroj génovej terapie

Bc. Braniskav Kusenda1, RNDr. Šárka Pospíšilová, Ph.D.2
1 Centrum molekulární biologie a genové terapie LF MU a FN Brno
2 Katedra genetiky, Univerzita Komenského, Prírodovedecká fakulta, Bratislava

RNA interferencia bola popísaná ako proces post-transkripčného utlmovania génovej expresie, sprostredkovaný dvojreťazcovými molekulami RNA, a ako obranný mechanizmus bunky proti vírusom a transpozónom. Porozumenie mechanizmu RNA interferencie umožnilo jeho experimentálne využitie na cielené utlmovanie génovej expresie a prinieslo zaujímavé informácie o spojitosti RNA interferencie a niektorých ochorení. Cielené utlmovanie génovej expresie umožňuje jednak detailné štúdium funkcie jednotlivých génov a stáva sa jedným z nových a nádejných prístupov pre génovú terapiu.

Keywords: Kľúčové slová: RNA interferencia, génová terapia, siRNA, miRNA.

Published: May 1, 2006  Show citation

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Kusenda B, Pospíšilová Š. RNA interferencia – nový nástroj génovej terapie. Neurol. praxi. 2006;7(2):69-71.
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