Neurol. praxi. 2007;8(6):360-362

Vliv antiepileptik na sexuální funkce

MUDr. Klára Látalová, doc. MUDr. Vladimír Pidrman, Ph.D.
Psychiatrická klinika FN a LF UP, Olomouc

Sexuální dysfunkce mohou být nepříjemným, nežádoucím efektem při léčně antiepileptiky. Dle klinických zkušeností se zdá, že tyto nežádoucí účinky jsou poměrně časté. Nicméně neexistuje dostatek kontrolovaných studií, které by stanovily přesnější míru výskytu sexuálních dysfunkcí u jednotlivých antiepileptik. Ukazuje se, že některá antiepileptika mají přímý vliv na hladiny pohlavních hormonů, jiná spíše ovlivňují sexuální chování. Terapie sexuálních dysfunkcí vyvolané antiepileptiky ponejvíce čerpá z údajů kazuistik, nebo malých nekontrolovaných sledováních a neexistují pro ni závazné postupy.

Published: January 15, 2008  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Látalová K, Pidrman V. Vliv antiepileptik na sexuální funkce. Neurol. praxi. 2007;8(6):360-362.
Download citation

References

  1. Bilo L, Meo R, Valentino R, Buscaino GA, Striano S, Nappi C. Abnormal pattern of luteinizing hormone pulsatility i women with epilepsy. Fertil Steril 1991; 55: 705-711. Go to original source... Go to PubMed...
  2. Bilo L, Meo R, Valentino R, Di Carlo C, Striano S, Nappi C. Characterization of reproductive endocrine disorders in women with epilepsy. J Clin Neurolol metab 2001; 86: 2950-2956. Go to original source... Go to PubMed...
  3. Clark JD, Elliot J. Gabapentin-induced anorgasmia. Neurology 1999; 53: 2209. Go to original source... Go to PubMed...
  4. Duncan S, Blacklaw J, Beastall GH, Brodie MJ. Antiepileptic drug therapy and sexual functin in men with epilepsy. Epilepsia 1999; 40: 197-204. Go to original source... Go to PubMed...
  5. Drislane FW, Coleman AE, Schomer DL et al. Altered pulsatile secretion of luteinizing hormone in women with epilepsy. Neurology, 1994: 44: 306-310. Go to original source... Go to PubMed...
  6. Erfurth A, Amann B, Grunze H. Female genital disorder as adverse symptom of lamotrigine treatment. Neuropsychobiology 1998; 38: 200-201. Go to original source... Go to PubMed...
  7. Grant AC, Oh H. Gabapentin-induced anorgasmia in women. Am J Psych 2002; 159: 1247. Go to original source... Go to PubMed...
  8. Husain AM, Carwil ST, Miller PP, Radtke RA. Improved sexual function in three men taking lamotrigine for epilepsy. South Med J, 200; 93: 335-336.
  9. Isojarvi JIT, Laatikanen TJ, Pakarinen AJ, Juntunen KTS, Myllala VV. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med 1993; 329: 1383-1388. Go to original source... Go to PubMed...
  10. Jensen P, Jensen SB, Sorensen PS et al. Sexual dysfunction in male and female patiens with epilepsy: a study of 86 outpatients. Arch Sex Nebav 1990; 19: 1-14. Go to original source... Go to PubMed...
  11. Lambert MV. Seizures, hormones, and sexuality. Seizure 2001; 10: 319-340. Go to original source... Go to PubMed...
  12. Mattson RH, Cramer JA, Collins JF et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985; 313; 145-151. Go to original source... Go to PubMed...
  13. Morrell MJ. Sexual dysfunction in epilepsy. Epilepsia 1991; 32(Suppl): S38-S45. Go to original source... Go to PubMed...
  14. Morrell MJ. Guldner GT - Self-reported sexual function and sexual arousability in women with epilepsy. Epilepsia, 1996; 37: 1204-1210. Go to original source... Go to PubMed...
  15. Penovich PE. The effects of epilepsy and its treatment on sexual and reproductive function. Epilepsia, 2000; 41(Suppl 2): S53-S61. Go to original source... Go to PubMed...
  16. Pimentel J. Current issues on epileptic women. Curr Pharm Des 2000; 6: 865-872. Go to original source... Go to PubMed...
  17. Rattya J, Turka J, Pakarinen AJ, et al. Reproductive effects of valproate, carbamazepine, and oxcarbamazepine in men with epilepsy. Neurology 2001; 56: 31-36. Go to original source... Go to PubMed...
  18. Segraves RT, Balon R. The impact of anticonvulsants on sexual functinon. Sexual pharmacology - fast facts. W.W. Norton & Company, Inc. 2003; 157-168.
  19. Sorensen AS, Bowling TG. Personality and epilepsy: new evidence for a relationship? A rewiew. Compr Psychiatry 1987; 28: 369-383. Go to original source... Go to PubMed...




Neurology for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.