Neurol. praxi. 2009;10(6):340-346

Treatment of Parkinson’s disease

prof.MUDr.Ivan Rektor, CSc.
Centrum pro abnormní pohyby a parkinsonizmus, I. neurologická klinika LF MU a FN u sv. Anny, Brno

Start of the therapy: L-dopa; DA-agonists; selegiline; amantadine; rasagiline; in patients older than 70 years L-dopa. When therapy

insufficient: add on/increase the standard or controlled-released L-dopa, COMT inhibitor; DA-agonists orally or in patch; rasagiline. Severe

motor complication: partial „drug holiday” with amantadine i. v.; apomorphine/lisuride s. c.; intraduodenal L dopa; surgery (DBS).

Psychiatric complications: graduall discontinuation of DA agonists, amantadine, MAO inhibitors, anticholinergics; to continue with the

minimal effective dose of L-dopa; atypical antipsychotics. Dementia: acetylcholinesterase inhibitors.

Keywords: Parkinson’s disease, treatment, drugs, surgery, dopaminergic

Published: January 1, 2010  Show citation

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Rektor I. Treatment of Parkinson’s disease. Neurol. praxi. 2009;10(6):340-346.
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