Neurol. praxi. 2009;10(6):378-383

Diabetic Neuropathy - Neurologist Perspective

MUDr.Radim Mazanec, Ph.D., doc.MUDr.Martin Bojar, CSc., MUDr.Tomáš Nedělka
Neurologická klinika, 2. LF UK a FN v Motole, Praha

Diabetic neuropathy, a common complication of diabetes mellitus type 1 and type 2, represents clinically heterogeneous syndrome

with various involvement of peripheral, cranial and autonomic nerves. The progression is usually slow and patients may stay for a long

time asymptomatic. Prevalence of diabetic neuropathy is estimated between 13 and 54 % according to the duration of the disease. Two

main clinical types of diabetic neuropathy – generalized and focal – can be distinguished by clinical examination. The basic diagnostic

tool is electromyography. The symptomatic treatment is focused on neuropathic pain. As the effective treatment is still unavailable

diabetic neuropathy represents a high risk for development of diabetic foot. It is very important to differentiate other causes leading to

neuropathy in diabetic patient as this may lead to causative and usually more effective therapy.

Keywords: diabetic neuropathy, diabetic foot, electromyography, neuropathic pain

Published: January 1, 2010  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Mazanec R, Bojar M, Nedělka T. Diabetic Neuropathy - Neurologist Perspective. Neurol. praxi. 2009;10(6):378-383.
Download citation

References

  1. Adler AJ, Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, Smith DG. Risk factors for diabetic peripheral sensory neuropathy. Diabetes Care 1997; 20: 1162-1167. Go to original source... Go to PubMed...
  2. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, La Moreaux L, Garofalo. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: A randomized controlled trial. JAMA 1998; 280: 1831-1836. Go to original source... Go to PubMed...
  3. Consensus statement. Report and recommendations of the San Antonio conference on diabetic neuropathy. Diabetes Care 1988; 11: 592-597. Go to original source... Go to PubMed...
  4. Dallocchio C, Buffa C, Mazzarello P, Chiroli S. Gabapentin vs. amitriptyline in painful diabetic neuropathy: An open-label pilot study. Journal of Pain and Symptom Management October 2000; 20: 280-285. Go to original source... Go to PubMed...
  5. Daousi C, MacFarlane IA, Woodward A, Nurmikko TJ, Bundred PE, Benbow SJ. Chronic painful peripheral neuropathy in an urban community: a controlled comparison of people with and without diabetes. Diabetes Med. 2004; 21(9): 976-982. Go to original source... Go to PubMed...
  6. Diabetes Control and Complication Trial (DCCT) Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977-986. Go to original source... Go to PubMed...
  7. Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, Wilson DM, O´Brien PC, Melton LJ. The prevalence by stagged severity of various types of diabetic neuropathy, retinopathy and neuropathy in popu lation based cohort: The Rochester Diabetic Neuropathy Study. Neurology 1993; 43: 817-824. Go to original source... Go to PubMed...
  8. Dyck PJ, Thomas PK. Peripheral neuropathy. 3rd Edition; Elsevier Saunders, 2005.
  9. Kožnarová R, Saudek F, Sosna T, Vondrová H. Průběh pozdních komplikací diabetu po úspěšné kombinované transplantaci ledviny a pankreatu. Výsledek 5-letého sledování. V. konference Transplantace orgánů a tkání Brno 2002. Sborník abstrakt 2002: 26.
  10. Nicolucci A, Carinci F, Cavaliere D, Scorpiglione N, Belfiglio M, Labbrozzi D, Mari E, Benedetti MM, Tognoni G, Liberati A. A meta-analysis of trials on aldoso reductase inhibitors in diabetic peripheral neuropathy. Diabet Med 1996; 13: 1017-1026. Go to original source... Go to PubMed...
  11. Malik RA, Williamson S, Abbott C, Carrington AL, Iqbal J, Schady W, Boulton AJ. Effect of angiotensin - converting-enzymes (ACE) inhibitor trandolapril on human diabetic neuropathy: randomised double blind controlled trial. Lancet 1998; 352: 1978-1981. Go to original source... Go to PubMed...
  12. Moravcová E, Bednařík J. Diabetická neuropatie. Neurol. pro praxi 2006; 2: 99-103.
  13. Pickup JC, Williams G. Texbook of Diabetes. 3rd edition. Blackwell Science 2003; Chapter 50 a 51.
  14. Said G, Goulon-Goeau C, Moulonquet A. A nerve biopsy findings in different patterns of proximal diabetic neuropathy. AnnNeurol 1994; 35: 559-569. Go to original source... Go to PubMed...
  15. Sand ML, Shetterly SM, Franklin GM, Hamman RF. Incidence of distal symmetric (sensory) neuropathy in NIDDM. The San Luis Valley Diabetes Study. Diabetes Care 1997; 20(3): 322-329. Go to original source... Go to PubMed...
  16. Saudek F, Adamec M, Bouček P, Kožnarová R, Lipór K, Janoušek L, Vlasáková Z, Lónská V, Bartoš V. Tři sta transplantací pankreatu v Institutu klinické a experimentální mediciny v Praze. Prakt Lék 2007; 87(2): 76-81.
  17. Shaw JE, Zimmet PZ. The epidemiology of diabetic neuropathy. Diabetes Rev. 1999; 7: 245-252.
  18. Thomas PK. Classification, differential diagnosis and staging of diabetic peripheral neuropathy. Diabetes 1997; 46(Suppl.2): 54-57. Go to original source... Go to PubMed...
  19. Vinik AI, Bril V, Kempler P, Litchy WJ, Tesfaye S, Price KL, Bastyr EJ. Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo controlled, double-blind clinical trial. ClinTher 2005; 27(8): 1164-1180. Go to original source...
  20. Vlčková-Moravcová E, Bednařík J, Bělobradková J, Sommer C. Small. fibre involvement in diabetic patients with neuropathic foot pain. Diabet Med. 2008; 25(6): 692-699. Go to original source... Go to PubMed...
  21. Vondrová H. Léčba diabetické polyneuropatie. Neurol pro praxi 2008; 9: 245-251.
  22. Wiggin TD, Sullivan KA, Pop-Busui R, Amato A, Sima AA, Feldman EL. Elevated triglycerides correlate with progression of diabetic neuropathy. Diabetes 2009; 58(7): 1634-1640. Go to original source... Go to PubMed...
  23. Young MJ, Boulton AJM, Macleod AF, Williams DR, Skonsen PH. A multicentre study of the prevalence of diabetic neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993; 36: 150-154. Go to original source... Go to PubMed...
  24. Ziegler D. Diagnosis, staging and epidemiology of diabetic peripheral neuropathy. Diab Nutr Metab 1994; 7: 342-348.
  25. Ziegler D, Hanefeld M, Ruhnau KJ, Meisner HP, Lobisch M, Schütte K, Gries FA. The ALADIN Study Group. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha lipoic acid. Diabetologia 1995; 38: 1425-1433. Go to original source... Go to PubMed...
  26. Ziegler D, Gries FA, Spuler, Lessmann F. The epidemiology of diabetic neuropathy. DiaCAN Multicenter Study Group. Diabet. Med. 1993; Suppl2: 82. Go to original source...
  27. Zochodne DW, Said G. Recombinant human nerve growth factor and diabetic polyneuropathy. Neurology 1998; 51: 662-663. Go to original source... Go to PubMed...




Neurology for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.