Neurol. praxi. 2011;12(1):8-11

Tardive dystonia

MUDr.Michal Marąálek, CSc.
Psychiatrická léčebna Praha-Bohnice

Tardive dystonia is chronic symptomatic disorder of extrapyramidal system induced by long-term treatment with antipsychotics. Tardive

dyskinesia, acute dystonia and dystonias of another origin must be ruled out in differential diagnosis. Younger age, male gender, and

presence of other hyperkinetic extrapyramidal syndromes seem to be the main risk factors. Antipsychotic withdrawal, GABAergic agents,

anticholinergics, clozapine, botulinum toxin injection, and brain deep stimulation are recommanded for managing TDt.

Keywords: tardive dystonia, diagnosis, pathophysiology, epidemiology, treatment

Published: February 18, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Marąálek M. Tardive dystonia. Neurol. praxi. 2011;12(1):8-11.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Aggarwal A, Jiloha RC. Olanzapine induced tardive dystonia. Indian J Pharmacol. 2008; 40: 237-238. Go to original source... Go to PubMed...
    2. Aukst-Margetić B, Margetić B. Treatment of generalized tardive dystonia with clozapine. Psychiatr Danub 2008; 20: 329-331. Go to PubMed...
    3. Bressman SB, de Leon D, Raymond D, Greene PE, Brin MF, Fahn S, Ozelius LJ, Breakefield XO, Kramer PL, Risch NJ. Secondary dystonia and the DYTI gene. Neurology 1997; 48: 1571-1577. Go to original source... Go to PubMed...
    4. Burke RE, Fahn S, Jankovic J, Marsden CD, Lang AE, Gollomp S, Ilson J. Tardive dystonia: late-onset and persistent dystonia caused by antipsychotic drugs. Neurology 1982; 32: 1335-1346. Go to original source... Go to PubMed...
    5. Correll CU, Leucht S, Kane JM. Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies. Am J Psychiatry 2004; 161: 414-425. Go to original source... Go to PubMed...
    6. Friedman JH. Tardive dystonia due to aripiprazole use in a neuroleptic-naive patient. J Clin Psychiatry 2010; 71: 652-653. Go to original source... Go to PubMed...
    7. Greene P. Tardive dystonia. In: Yassa R, Nair NPV, Jeste DV, eds. Neuroleptic-induced movement disorders. 1st edn. Cambridge: Cambridge University Press, 1997: 395-408. Go to original source...
    8. Gunes A, Dahl ML, Spina E, Scordo MG. Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patients. Eur J Clin Pharmacol. 2008; 64: 477-482. Go to original source... Go to PubMed...
    9. Güzey C, Scordo MG, Spina E, Landsem VM, Spigset O. Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms. Eur J Clin Pharmacol. 2007; 63: 233-241. Go to original source... Go to PubMed...
    10. Hashimoto T, Naito K, Kitazawa K, Imai S, Goto T. Pallidotomy for severe tardive jaw-opening dystonia. Stereotact Funct Neurosurg 2010; 88: 105-108. Go to original source... Go to PubMed...
    11. Hennings JM, Krause E, Bötzel K, Weber TC. Succesful treatment of tardive linguae dystonia with botulinum toxin: case report and review of the literature. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1167-1171. Go to original source... Go to PubMed...
    12. Hornykiewicz O, Kish SJ, Becker LE, Farley I, Shannak K. Brain neurotransmitters in dystonia musculorum deformans. N Engl J Med. 1986; 315: 347-533. Go to original source... Go to PubMed...
    13. Kang UJ, Burke RE, Fahn S. Natural history and treatment of tardive dystonia. Mov Disord 1986; 1: 193-208. Go to original source... Go to PubMed...
    14. Kaňovský P. Dystonia: a disorder of motor programming or motor execution? Mov Disord. 2002; 17: 1143-1147. Go to original source... Go to PubMed...
    15. Kato K, Andoh H, Matsumoto H. Case of tardive dystonia improved by aripiprazole. Psychiatry Clin Neurosci 2010; 64: 337-338. Go to original source... Go to PubMed...
    16. Kiriakakis V, Bhatia KP, Quinn NP, Marsden CD. The natural history of tardive dystonia. A long-term follow-up study of 107 cases. Brain. 1998; 121: 2053-2066. Go to original source... Go to PubMed...
    17. Lim HK, Pae CU, Lee C, Lee CU. Tardive dystonic symptoms associated with aripiprazole treatment. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 589-590. Go to original source... Go to PubMed...
    18. Manteghi A, Hojjat SK, Javanbakht A. Remission of tardive dystonia with electroconvulsive therapy. J Clin Psychopharmacol 2009; 29: 314-315. Go to original source... Go to PubMed...
    19. Marąálek M. Tardive drug-induced extrapyramidal syndromes. Pharmacopsychiatry (Berlin) 2000; 33(Suppl 1): 14-33. Go to original source... Go to PubMed...
    20. Marąálek M. Extrapyramidové polékové poruchy. In: Seifertová D, Praąko J, Horáček J, Höschl C. (eds.) Postupy v léčbě psychických poruch. Algoritmy České neuropsychofar makologické společnosti. 2. vyd. Praha: AMEPRA v Medical Tribune Cz, 2008: 500-520.
    21. Oommer E, Chand PK, Sharma PS. Aripiprazole-induced tardive dystonia. Prim Care Companion J Clin Psychiatry 2006; 8: 378-379. Go to original source...
    22. Mendhekar DN, Lohia D, Kataria PJ Tardive oculogyric crisis associated with amisulpride monotherapy. Postgrad Med. 2010; 56: 305-306. Go to original source... Go to PubMed...
    23. Mihara K, Kondo T, Higuchi H, Takahashi H, Yoshida K, Shimizu T, Kaneko S. Tardive dystonia and genetic polymorphisms of cytochrome P4502D6 and dopamine D2 and D3 receptors: a preliminary finding. Am J Med Genet. 2002; 114: 693-695. Go to original source... Go to PubMed...
    24. Owens DGC. A guide to the extrapyramidal side-effects of antipsychotic drugs. 1st edn. Cambridge: Cambridge University Press, 1999.
    25. Praharaj SK, Jana AK, Sarkar S, Sinha VK Olanzapine-induced tardive oculogyric crisis. J Clin Psychopharmacol. 2009; 29: 604-606. Go to original source... Go to PubMed...
    26. Rektor I, Rektorová I. Parkinsonova nemoc a příbuzná onemocnění v praxi. Praha: Triton, 1999.
    27. Růľička E, Roth J, Kaňovský P, Fiedler J, Hallett M, Havrdová E, Jankovic J, Mečíř P, Nevąímalová S, ©onka K, ®idovská J. Dyskinetické syndromy a onemocnění. Extrapyramidová onemocnění II. Praha: Galén, 2002.
    28. Skidmore F, Reich SG. Tardive dystonia Curr Treat Opt Neurology 2005; 7: 231-236. Go to original source... Go to PubMed...
    29. Speelman JD, Contarino MF, SchuurmanPR, Tijssen MAJ, De Bie RMA. Deep brain stimulation for dystonia: patient selection and outcomes. Eur J Neurology 2010; 17: 102-106. Go to original source... Go to PubMed...
    30. Sun R, Chen S, Le W, Krahl SE. Subthalamic nukleus stimulation for primary dystonia and tardive dystonia. Acta Neurochir Suppl. 2007; 97: 207-214. Go to original source... Go to PubMed...
    31. ©vestka J. Clozapin. Prototyp antipsychotik nové generace. Praha: Maxdorf, 1998.
    32. Tachikawa H, Suzuki T, Kawanishi Y, Hori M, Hori T, Shiraishi H. Tardive dystonia provoked by concomitantly administered risperidone. Psychiatry Clin Neurosci. 2000; 54: 503-505. Go to original source... Go to PubMed...
    33. Tarsy D, Kaufman D, Sethi KD, Rivner MH, Mohlo E, Factor S. An open-label study of botulinum toxin A for treatment of tardive dystonia. Clin Neuropharmacol 1997; 20: 90-93. Go to original source... Go to PubMed...
    34. Thaker GK, Nguyen JA, Strauss ME, Jacobson R, Kaup BA, Tamminga CA. Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy. Am J Psychiatry 1990; 147: 445-451. Go to original source... Go to PubMed...
    35. Tsai CS, Lee Y, Chang YY, Lin PY. Ziprasidone-induced tardive laryngeal dystonia: a case report. Gen Hosp Psychiatry 2008; 30: 277-279. Go to original source... Go to PubMed...
    36. Uzun Ö, Doruk A. Tardive oculogyric crisis during treatment with clozapine: Report of Three Cases. Clin Drug Invest 2007; 27: 861-864. Go to original source... Go to PubMed...
    37. van Harten PN, Kahn RS. Tardive dystonia. Schizophrenia Bull. 1999; 25: 741-748. Go to original source... Go to PubMed...
    38. van Harten PN, Matroos GE, Van Os J. The course of tardive dystonia in Afro Caribbean patients, a population-based study: the Curacao extrapyramidal syndromes study: VII. Schizophr Res. 2008; 98: 79-83. Go to original source... Go to PubMed...
    39. Walker JM, Matsumoto RR, Bowen WD, Gans DL, Jones KD, Walker FO. Evidence for a role of haloperidol-sensitive sigma-,,opiate" receptors in the motor effects of antipsychotic drugs. Neurology 1988; 38: 961-965. Go to original source... Go to PubMed...

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.