Neurol. praxi. 2012;13(3):171-173

Lambert-Eaton myasthenic syndrome in a child

MUDr.Jan Staněk1, MUDr.František Vlček2
1 Klinika dětské neurologie FN Ostrava
2 Neurologická klinika FN Ostrava

Lambert-Eaton myasthenic syndrome is a rare autoimunne presynaptic disorder of neuromuscular transmission. It is characterised by

muscle weakness, hyporeflexia and autonomic dysfunction. The syndrome is often associated with small cell lung carcinomas. It is a disease

of middle and older age. Rare cases have been reported in children. We present a 12-year boy with abnormal gait, slight bilateral

ptosis, hyporeflexia, xerostomia and vitiligo without evidence of neoplasms. High- frequency repetitive nerve stimulation with a large

increment and a P/Q- type calcium- channel antibodies level confirmed the diagnosis of the syndrome. Corticosteroids, azathioprine

and pyridostigmine improved patient´s weakness.

Keywords: Lambert-Eaton myasthenic syndrome, weakness, xerostomia, calcium- channels, increment, vitiligo

Published: May 31, 2012  Show citation

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Staněk J, Vlček F. Lambert-Eaton myasthenic syndrome in a child. Neurol. praxi. 2012;13(3):171-173.
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