Neurol. praxi. 2012;13(6):343-346

Autoimmune limbic encephalitis associated with LGI antibodies

MUDr.Pavlína Zborníková1, MUDr.Eva Krasulová1, MUDr.Petr Bušek1, MUDr.Petra Nytrová1, MUDr.Věra Peterová1,2, MUDr.Nataša Špačková1, prof.MUDr.Eva Havrdová, CSc.1
1 Neurologická klinika a Centrum klinických neurověd 1. LF UK a VFN v Praze
2 Oddělení magnetické rezonance, Radiodiagnostická klinika 1. LF UK a VFN v Praze

Autoimmune non–paraneoplastic encephalitis is underdiagnosed neurological disorder. Thanks to recent research progression in the

field of neuronal autoantibodies, neurologists are equipped with a new diagnostic tool and, therefore, are able to offer adequate immunosupressant

therapy to their patients. The case reported here is a 67 year old man who presented with limbic encephalitis with memory

disorder and partial epileptic seizures. These symptoms resolved after treatment with intravenous immunoglobulines. We have found

LGI1 antibodies in this patient, antibodies targeted against one of components of voltage-gated potassium channels (VGKC) complexes.

Keywords: limbic encephalitis, autoimmune encephalitis, neuronal antibodies, LGI1 antibodies, VGKC antibodies

Published: December 1, 2012  Show citation

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Zborníková P, Krasulová E, Bušek P, Nytrová P, Peterová V, Špačková N, Havrdová E. Autoimmune limbic encephalitis associated with LGI antibodies. Neurol. praxi. 2012;13(6):343-346.
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