Neurol. praxi. 2013;14(6):305-308

Sleep disturbances in Parkinson’s disease

MUDr.Petr Dušek, MUDr.Lenka Plchová
Neurologická klinika a Centrum klinických neurověd, Univerzita Karlova v Praze, 1. LF a VFN v Praze

Sleep-Wake disturbances belong to the most common and disabling nonmotor symptoms of Parkinson‘s disease (PD) as they affect 50–95%

patients. Etiology of impaired sleep and wakefulness in PD is multifactorial. Its most important causes are co-existent primary sleep disorders,

medication side effects, overnight re-emergence of motor symptoms, psychiatric comorbidities and primary neurodegeneration of sleep

regulating brain areas itself. To date, very few controlled studies are available to make a recommendation for their management, thus treatment

of sleep-wake disturbances in PD must be tailored individually with respect to presence of comorbidities and patients preferences.

Keywords: Parkinson’s disease, insomnia, excessive daytime sleepiness, sleep apnea, restless legs syndrome, REM sleep behavior disorder

Published: December 1, 2013  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Dušek P, Plchová L. Sleep disturbances in Parkinson’s disease. Neurol. praxi. 2013;14(6):305-308.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    LMm_References

    1. Arnulf I, Konofal E, Merino-Andreu M, Houeto JL, Mesnage V, Welter ML, Lacomblez L, Golmard JL, Derenne JP, Agid Y. Parkinson's disease and sleepiness: an integral part of PD. Neurology 2002; 58: 1019-1024. Go to original source... Go to PubMed...
    2. Arnulf I, Leu-Semenescu S. Sleepiness in Parkinson's disease. Parkinsonism Relat Disord 2009; 15(Suppl 3): S101-104. Go to original source... Go to PubMed...
    3. Bruin VM, Bittencourt LR, Tufik S. Sleep-wake disturbances in Parkinson's disease: current evidence regarding diagnostic and therapeutic decisions. Eur Neurol 2012; 67: 257-267. Go to original source... Go to PubMed...
    4. Cochen De Cock V, Abouda M, Leu S, Oudiette D, Roze E, Vidailhet M, Similowski T, Arnulf I. Is obstructive sleep apnea a problem in Parkinson's disease? Sleep Med 2010; 11: 247-252. Go to original source... Go to PubMed...
    5. De Cock VC, Vidailhet M, Arnulf I. Sleep disturbances in patients with parkinsonism. Nat Clin Pract Neurol 2008; 4: 254-266. Go to original source... Go to PubMed...
    6. De Cock VC, Vidailhet M, Leu S, Texeira A, Apartis E, Elbaz A, Roze E, Willer JC, Derenne JP, Agid Y, Arnulf I. Restoration of normal motor control in Parkinson's disease during REM sleep. Brain 2007; 130: 450-456. Go to original source... Go to PubMed...
    7. Diederich NJ, Mcintyre DJ. Sleep disorders in Parkinson's disease: many causes, few therapeutic options. J Neurol Sci 2012; 314: 12-9. Go to original source... Go to PubMed...
    8. Frucht S, Rogers JD, Greene PE, Gordon MF, Fahn S. Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology 1999; 52: 1908-1910. Go to original source... Go to PubMed...
    9. Gagnon JF, Bedard MA, Fantini ML, Petit D, Panisset M, Rompre S, Carrier J, Montplaisir J. REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. Neurology 2002; 59: 585-589. Go to original source... Go to PubMed...
    10. Gjerstad MD, Boeve B, Wentzel-Larsen T, Aarsland D, Larsen JP. Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time. J Neurol Neurosurg Psychiatry 2008; 79: 387-391. Go to original source... Go to PubMed...
    11. Gjerstad MD, Wentzel-Larsen T, Aarsland D, Larsen JP. Insomnia in Parkinson's disease: frequency and progression over time. J Neurol Neurosurg Psychiatry 2007; 78: 476-479. Go to original source... Go to PubMed...
    12. Gomez-Esteban JC, Tijero B, Somme J, Ciordia R, Berganzo K, Rouco I, Bustos JL, Valle MA, Lezcano E, Zarranz JJ. Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson's disease. J Neurol 2011; 258: 494-499. Go to original source... Go to PubMed...
    13. Chahine LM, Ahmed A, Sun Z. Effects of STN DBS for Parkinson's disease on restless legs syndrome and other sleep-related measures. Parkinsonism Relat Disord 2011; 17: 208-211. Go to original source... Go to PubMed...
    14. Juri C, Chana P, Tapia J, Kunstmann C, Parrao T. Quetiapine for insomnia in Parkinson disease: results from an open-label trial. Clin Neuropharmacol 2005; 28: 185-187. Go to original source... Go to PubMed...
    15. Louter M, Aarden WC, Lion J, Bloem BR, Overeem S. Recognition and diagnosis of sleep disorders in Parkinson's disease. J Neurol 2012a; 259: 2031-2040. Go to original source... Go to PubMed...
    16. Louter M, Munneke M, Bloem BR, Overeem S. Nocturnal hypokinesia and sleep quality in Parkinson's disease. J Am Geriatr Soc 2012b; 60: 1104-1108. Go to original source... Go to PubMed...
    17. Lyons KE, Friedman JH, Hermanowicz N, Isaacson SH, Hauser RA, Hersh BP, Silver DE, Tetrud JW, Elmer LW, Parashos SA, Struck LK, Lew MF, Pahwa R. Orally disintegrating selegiline in Parkinson patients with dopamine agonist-related adverse effects. Clin Neuropharmacol 2010; 33: 5-10. Go to original source... Go to PubMed...
    18. Menza M, Dobkin RD, Marin H, Gara M, Bienfait K, Dicke A, Comella CL, Cantor C, Hyer L. Treatment of insomnia in Parkinson's disease: a controlled trial of eszopiclone and placebo. Mov Disord 2010; 25: 1708-14. Go to original source... Go to PubMed...
    19. Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 2002; 59: 421-424. Go to original source... Go to PubMed...
    20. Poryazova R, Benninger D, Waldvogel D, Bassetti CL. Excessive daytime sleepiness in Parkinson's disease: characteristics and determinants. Eur Neurol 2010; 63: 129-135. Go to original source... Go to PubMed...
    21. Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009; 72: 1296-1300. Go to original source... Go to PubMed...
    22. Srinivasan V, Cardinali DP, Srinivasan US, Kaur C, Brown GM, Spence DW, Hardeland R, Pandi-Perumal SR. Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection. Ther Adv Neurol Disord 2011; 4: 297-317. Go to original source... Go to PubMed...
    23. Tan EK, Seah A, See SJ, Lim E, Wong MC, Koh KK. Restless legs syndrome in an Asian population: A study in Singapore. Mov Disord 2001; 16: 577-579. Go to original source... Go to PubMed...
    24. Tandberg E, Larsen JP, Karlsen K. A community-based study of sleep disorders in patients with Parkinson's disease. Mov Disord 1998; 13: 895-899. Go to original source... Go to PubMed...
    25. Trenkwalder C, Kohnen R, Hogl B, Metta V, Sixel-Doring F, Frauscher B, Hulsmann J, Martinez-Martin P, Chaudhuri KR. Parkinson's disease sleep scale - validation of the revised version PDSS-2. Mov Disord 2011; 26: 644-652. Go to original source... Go to PubMed...
    26. Trotti LM, Bliwise DL. No increased risk of obstructive sleep apnea in Parkinson's disease. Mov Disord 2010; 25: 2246-2249. Go to original source... Go to PubMed...
    27. Videnovic A, Golombek D. Circadian and sleep disorders in Parkinson's disease. Exp Neurol 2012. Go to original source... Go to PubMed...

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.