Neurol. praxi. 2014;15(3):155-157
Long-term treatment with intraduodenal levodopa - case report of three patients
- 1 Centrum pro abnormní pohyby a parkinsonizmus, I. neurologická klinika FN u sv. Anny a LF MU, Brno
- 2 Gastroenterologické oddělení, II. interní klinika FN u sv. Anny a LF MU, Brno
We present case reports of three patients with Parkinson‘s disease (PD) treated with intradudodenal levodopa – Duodopa. Duodopa enables continuous administration of dopaminergicv treatment indicated for patients with late motor complications. Administration of levodopa into the jejunal part of duodenum and easy dose setting leads to stable plasma levels of levodopa and an improvement of motor state of patients with PD. This invasive procedure plays an important role in therapy of late motor complications of PD.
Keywords: Parkinson´s disease, intraduodenal levodopa, case reports
Published: June 9, 2014 Show citation
References
- Antonini A, Odin P. Pros and cons of apomorphine and L-dopa continuous infusion in advanced Parkinson's disease. Parkinsonism Relat Disord. 2009; (Suppl 4): S97-100.
Go to original source... 
Go to PubMed... - Bareš M. Pozdní hybné komplikace Parkinsonovy nemociwearing-off fenomén a další motorické komplikace. Neurol. praxi 2008; 9(2): 96-99.
- Gershanik O, Jenner P. Moving from continuous dopaminergic stimulation to continuous drug delivery in the treatment of Parkinson's disease. Eur J Neurol. 2012; 19(12): 1502-1508. Go to original source... Go to PubMed...
- Honig H, Antonini A, Martinez-Martin P, Forgacs I, Faye GC, Fox T, Fox K, Mancini F, Canesi M, Odin P, Chaudhuri KR. Intrajejunal levodopa infusion in Parkinson's disease: a pilot multicenter study of effects on nonmotor symptoms and quality of life. Mov Disord. 2009 Jul 30; 24(10): 1468-1474. Go to original source... Go to PubMed...
- de Lau LML, Giesbergen PCLM, de Rijk MC Hofman A, Koudstaal PJ, Breteler MM. Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study. Neurology. 2004; 63: 1240-1244. Go to original source... Go to PubMed...
- Nyholm D. Enteral levodopa/carbidopa gel infusion for the treatment of motor fluctuations and dyskinesias in advanced Parkinson's disease. Expert Rev Neurother. 2006, Oct; 6(10): 1403-1411. Go to original source... Go to PubMed...
- Wright BA, Waters CH. Continuous dopaminergic delivery to minimize motor complications in Parkinson's disease. Expert Rev Neurother. 2013 Jun; 13(6): 719-729. Go to original source... Go to PubMed...