Neurol. praxi. 2017;18(3):179-185 | DOI: 10.36290/neu.2017.082
New perspectives of the treatment of migraine
- Neurologická klinika LF UK a FN Plzeň
The acute treatment of migraine attacks is so far limited to the use of simple analgesics, non-steroidal anti-inflammatory drugs,
ergotamines and triptans. On the basis of our knowledge about pathophysiology of migraine, which is mentioned in this article,
new medicaments for the treatment of acute migraine attacks have been developed targeted especially to calcitonin gene–related
peptide (CGRP) and serotonin 5-HT1F receptors. Other therapeutic targets are mentioned, such as glutamate, combination of 5-HT-
1B/1D receptors and neuronal nitric oxide synthesis and medicament influencing cortical spreading depression. In the prophylaxis
of migraine, the most promising new approach are humanized antibodies against CGRP or the CGRP receptor. Non – invasive and
invasive neuromodulation techniques are being developed at present in the acute and prophylactic treatment.
Keywords: calcitonin gene-related peptid (CGRP), serotonin 5-HT1F receptors, nitric oxide, glutamate, cortical spreading depression, monoclonal antibodies against CGRP or CGRP receptors, anticonvulsant drugs
Published: July 1, 2017 Show citation
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