Neurol. praxi. 2017;18(5):342-345 | DOI: 10.36290/neu.2017.013

Case reports of sporadic variants of Creutzfeldt-Jakob disease

MUDr. Tereza Lukoszová

Neurologické oddělení, Nemocnice Havlíčkův Brod

Prion diseases are the group of rare neurodegenerative diseases affecting both humans and animals, characterized by a longincubation period, rapidly progressing symptoms and infaust prognosis without the possibility of influencing the course of diseaseby therapy. The basic pathophysiological process is accumulation of "infectious" protein – prion in the brain tissue with itsirreversible spongiform damage. The most common human prion disease is Creutzfeldt-Jakob disease. It should be considered indifferential diagnostic process especially in cases of rapidly progressive dementia in combination with other neurological symptoms.The aim of this article is to really point out the issue of prion diseases and to briefly describe it in following case-reports ofsporadic Creutzfeldt-Jakob disease which was diagnosed at our department in years 2015 and 2016.

Keywords: prion diseases, prion, sporadic Creutzfeldt-Jakob disease, dementia

Received: March 6, 2017; Accepted: March 31, 2017; Published: November 1, 2017  Show citation