Neurol. praxi. 2017;18(6):415-421 | DOI: 10.36290/neu.2017.045

Lewy body dementia with the clinical picture of sporadic Creutzfeldt-Jakob´s disease

MUDr. Eva Pešlová1, 2, prof. MUDr. Milan Brázdil, Ph.D.1, prof. MUDr. Irena Rektorová Ph.D.1
1 I. neurologická klinika, LF MU a FN u sv. Anny v Brně
2 Stipendistka programu Brno Ph.D. Talent

We present here a case study of a patient suffering from rapidly progressive dementia with the clinical picture of Creutzfeldt-Jakob´s disease, which finally turned out to be a masked Lewy body dementia in which the dissection showed an influence ofother comorbidities. Lewy body dementia is in general underdiagnosed condition and there is a little clinical awareness. Thiscase study shows the need of familiarity with the diagnostic criteria of dementias. It is necessary to keep in mind the possibilityof combination of multiple diagnosis and brain pathologies which could produce an atypical clinical picture.

Keywords: dementia, Lewy body dementia, sporadic Creutzfeldt Jakob's disease, primary age-related tauopathy

Received: September 20, 2017; Accepted: October 17, 2017; Published: December 1, 2017  Show citation

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Pešlová E, Brázdil M, Rektorová I. Lewy body dementia with the clinical picture of sporadic Creutzfeldt-Jakob´s disease. Neurol. praxi. 2017;18(6):415-421. doi: 10.36290/neu.2017.045.
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    References

    1. Blennow K, Johansson A, Zetterberg H. Diagnostic value of 14-3-3beta immunoblot and T-tau/P-tau ratio in clinically suspected Creutzfeldt-Jakob disease. Int. J. Mol. Med. 2005; 16: 1147-1149. Go to original source...
    2. Boot BP, McDade EM, McGinnis SM, Boeve BF. Treatment of dementia with lewy bodies. Curr. Treat. Options Neurol. 2013; 15: 738-764. Go to original source... Go to PubMed...
    3. Caviness JN, Adler CH, Caselli RJ, Hernandez JL. Electrophysiology of the myoclonus in dementia with Lewy bodies. Neurology 2003; 60: 523-524. Go to original source... Go to PubMed...
    4. Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof, PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL, Wisniewski T, Woltjer RL, Yamada M, Nelson PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. (Berl.) 2014; 128: 755-766. Go to original source... Go to PubMed...
    5. Delli Pizzi S, Franciotti R, Tartaro A, Caulo M, Thomas A, Onofrj M, Bonanni L. Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study. PloS One 2014; 9: e86624. Go to original source... Go to PubMed...
    6. Gaig C, Valldeoriola F, Gelpi E, Ezquerra M, Llufriu S, Buongiorno M, Rey MJ, Martí MJ, Graus F, Tolosa E. Rapidly progressive diffuse Lewy body disease. Mov. Disord. 2011; 26: 1316-1323. Go to original source... Go to PubMed...
    7. Ha?k S, Brandel JP, Sazdovitch V, Delasnerie-Laupr?tre N, Peoc'h K, Laplanche JL, Privat N, Duyckaerts C, Kemeny JL, Kopp N, Laquerri?re A, Mohr M, Deslys JP, Dormont D, Hauw JJ. Dementia with Lewy bodies in a neuropathologic series of suspected Creutzfeldt-Jakob disease. Neurology 2000; 55: 1401-1404. Go to original source... Go to PubMed...
    8. Hanagasi HA, Bilgiç B, Emre M. Neuroimaging, biomarkers, and management of dementia with Lewy bodies. Front. Neurol. 2013; 4: e151. Go to original source... Go to PubMed...
    9. Hyeon JW, Kim SY, Lee J, Park JS, Hwang KJ, Lee SM, An SA, Lee MK, Ju YR. Alternative application of Tau protein in Creutzfeldt-Jakob disease diagnosis: Improvement for weakly positive 14-3-3 protein in the laboratory. Sci. Rep. 2015; 5: e15283. Go to original source... Go to PubMed...
    10. Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Lancet Neurol. 2017; 16: 55-65. Go to original source... Go to PubMed...
    11. Johnson RT, Gibbs CJ. Creutzfeldt-Jakob disease and related transmissible spongiform encephalopathies. N. Engl. J. Med. 1998; 339: 1994-2004. Go to original source... Go to PubMed...
    12. Kovacs GG, Milenkovic I, Wöhrer A, Höftberger R, Gelpi E, Haberler C, Hönigschnabl S, Reiner-Concin A, Heinzl H, Jungwirth S, Krampla W, Fischer P, Budka H. Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series. Acta Neuropathol. (Berl.) 2013; 126: 365-384. Go to original source... Go to PubMed...
    13. Manix M, Kalakoti P, Henry M, Thakur J, Menger R, Guthikonda B, Nanda A. Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy. Neurosurg. Focus 2015; 39: E2. Go to original source... Go to PubMed...
    14. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings, J., Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn, A, Kosaka, K, Lee VMY, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska, EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65: 1863-1872. Go to original source... Go to PubMed...
    15. Otto M, Cepek L, Ratzka P, Doehlinger S, Boekhoff I, Wiltfang J, Irle E, Pergande G, Ellers-Lenz B, Windl O, Kretzschmar HA, Poser S, Prange H. Efficacy of flupirtine on cognitive function in patients with CJD: a double-blind study. Neurology 2004; 62: 714-718. Go to original source... Go to PubMed...
    16. Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G. Abolishing the 1-year rule: How much evidence will be enough? Mov. Disord. Off. J. Mov. Disord. Soc. 2016; 31: 1623-1627. Go to original source... Go to PubMed...
    17. Ragno M, Scarcella MG, Cacchi? G, Capellari S, Di Marzio F, Parchi P, Trojano L. Striatal [123I] FP-CIT SPECT demonstrates dopaminergic deficit in a sporadic case of Creutzfeldt-Jakob disease. Acta Neurol. Scand. 2009; 119: 131-134. Go to original source... Go to PubMed...
    18. Rektorová I. Kognitivní a behaviorální poruchy u demence při Parkinsonově nemoci a u demence s Lewyho tělísky. Neurol. praxi 2005; 7: 21-25.
    19. Rektorova I. Neurodegenerativní demence. Ceska Slov. Neurol. Neurochir. 2009; 72: 97-109.
    20. Rohan Z, Parobková E, Johanidesová S, Koukolík F, Matěj R, Rusina R. Lidské prionové nemoci v České republice - 10 let zkušeností s diagnostikou. Čes. Slov. Neurol. Neurochir. Časopis Čes. Slov. Neurol. Neurochir. 2013; 76: 300-306.
    21. Rohan Z, Rusina R, Marešová M, Matěj R. [Human prion diseases in the Czech Republic]. Epidemiol. Mikrobiol. Imunol. Cas. Spolecnosti Epidemiol. Mikrobiol. Ceske Lek. Spolecnosti JE Purkyne 2015; 64: 115-120.
    22. Rusina R, Matěj R. Neurodegenerativní onemocnění. Mladá fronta, Praha. 2014.
    23. Stoeck K, Sanchez-Juan P, Gawinecka J, Green A, Ladogana A, Pocchiari M, Sanchez-Valle R, Mitrova E, Sklaviadis T, Kulczycki J, Slivarichova D, Saiz A, Calero M, Knight R, Aguzzi A, Laplanche JL, Peoc'h K, Schelzke G, Karch A, van Duijn CM, Zerr I. Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years. Brain J. Neurol. 2012; 135: 3051-3061. Go to original source... Go to PubMed...
    24. Tola-Arribas MA, Yugueros MI, Garea MJ, Ortega-Valín F, Cerón-Fernández A, Fernández-Malvido B, San José-Gallegos A, González-Touya M, Botrán-Velicia A, Iglesias-Rodríguez V, Díaz-Gómez B. Prevalence of dementia and subtypes in Valladolid, northwestern Spain: the DEMINVALL study. PloS One 2013; 8: e77688. Go to original source... Go to PubMed...
    25. Walker Z, Possin KL, Boeve BF, Aarsland D. Lewy body dementias. Lancet Lond. Engl. 2015; 386: 1683-1697. Go to original source... Go to PubMed...
    26. Wang HF, Yu JT, Tang SW, Jiang T, Tan CC, Meng XF, Wang C, Tan MS, Tan L. Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis. J Neurol Neurosurg Psychiatry 2015; 86: 135-143. Go to original source... Go to PubMed...
    27. Watson R, Blamire AM, Colloby SJ, Wood JS, Barber, R, He J, O'Brien JT. Characterizing dementia with Lewy bodies by means of diffusion tensor imaging. Neurology 2012; 79: 906-914. Go to original source... Go to PubMed...
    28. Yamada M. [Primary age-related tauopathy (PART): a novel term to describe age-related tangle pathology encompassing a wide range from cognitively normal condition to senile dementia of the neurofibrillary tangle type]. Nihon Rinsho Jpn. J. Clin. Med. 2016; 74: 471-475.
    29. Zerr I, Kallenberg K, Summers DM, Romero C, Taratuto, A, Heinemann U, Breithaupt M, Varges D, Meissner B, Ladogana A, Schuur M, Haik S, Collins SJ, Jansen GH, Stokin, GB, Pimentel J, Hewer E, Collie D, Smith P, Roberts H, Brandel JP, van Duijn C, Pocchiari M, Begue C, Cras P, Will RG, Sanchez-Juan P. Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease. Brain J. Neurol. 2009; 132: 2659-2668. Go to original source...

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