Neurol. praxi 2017; 18(Suppl F): 18-21
MRI efficacy of subcutaneous interferon ß-1a in treating multiple sclerosis
- Neurologické oddělení Nemocnice Jihlava
Magnetic resonance imaging is an important tool in establishing the diagnosis of multiple sclerosis as well as in subsequentlymonitoring the success of immunomodulatory therapy in patients already diagnosed with the disease. Clinical signs are presentonly in a proportion of inflammatory lesions of the brain and spinal cord, and it is magnetic resonance imaging that helps to monitorthe clinically silent phase of the disease. Early treatment initiation is important for prognosis of the disease since irreversibleneurodegeneration occurs already at the onset of the disease. Subcutaneous interferon ß-1a was shown to have significant efficacyin reducing MRI activity also in patients with a higher disease activity at treatment initiation in the IMPROVE trial. Moreover, inthe EVIDENCE trial, it was confirmed to have a higher efficacy in reducing the observed MRI parameters when directly comparedwith interferon ß-1a administered intramuscularly once a week.
Keywords: multiple sclerosis, interferon ß-1a, magnetic resonance imaging, NEDA
Published: December 1, 2017 Show citation
