Neurol. praxi. 2020;21(1):27-30 | DOI: 10.36290/neu.2020.009

Deep brain stimulation in the treatment of dystonia

doc. MUDr. Marek Baláž, Ph.D.¹, MUDr. Zuzana Košutzká, PhD.², doc. MUDr. Jan Chrastina, Ph.D.³

¹ I. neurologická klinika LF MU a FN u sv. Anny, Brno

² II. neurologická klinika LF UK a UNB, Nemocnica akademika L. Dérera, Bratislava

³ Neurochirurgická klinika LF MU a FN u sv. Anny, Brno

Deep brain stimulation (DBS) is an established treatment method in cases of dystonia that are not responding to peroral medication and/or targeted botulinum toxin therapy. The most frequently used surgical target for electrode insertion is internal part of globus pallidum (GPi). Young patients with short disease duration benefit most from this surgical method. Cases of isolated dystonia, generalised dystonia with phasic elements or tardive dystonia appear to respond most to DBS GPi. Many of the double-blind clinical studies show improvement of not only motor, but also non-motor symptoms of dystonia. Predictive factors for successful DBS in dystonia are subject of an ongoing research. In cases where dystonia limits the quality of life despite the optimalised pharmacotherapy should be patients without major comorbidities referred to specialised center for DBS consideration

Keywords: deep brain stimulation, DBS, dystonia.

Received: January 10, 2020; Revised: January 27, 2020; Accepted: January 27, 2020; Prepublished online: January 27, 2020; Published: March 30, 2020  Show citation