Neurol. praxi. 2022;23(5):389-393

The role of corticosteroids in the treatment of epilepsy

MUDr. Klára ©panělová, MUDr. Katarína Česká, MUDr. ©tefánia Aulická, Ph.D.
Klinika dětské neurologie LF MU a FN Brno, Centrum pro epilepsie Brno

The inflammatory processes in the brain are a part of the pathophysiological mechanism; involved in epileptogenesis, an onset of seizure activity and the development of drug resistance. The endogenous anti-inflammatory response fails, and the inflammation develops during recurrent seizures or status epilepticus. Thus, it plays a crucial role in the retaining seizure activity and the continuing seizures. A relation between inflammation and epilepsy is, therefore, reciprocal. Corticoids and ACTH partly mediate the anticonvulsant effect by their anti-inflammatory characteristics. The corticosteroids have achieved a wide range of use in epileptology, both in the chronic treatment of drug-resistant epilepsy and as a part of acute management of new-onset refractory status epilepticus, thanks to their complex effect.

Keywords: corticoids, corticosteroids, inflammation, therapy, side effects.

Received: March 2, 2022; Revised: March 2, 2022; Accepted: March 17, 2022; Prepublished online: March 17, 2022; Published: October 6, 2022  Show citation

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©panělová K, Česká K, Aulická ©. The role of corticosteroids in the treatment of epilepsy. Neurol. praxi. 2022;23(5):389-393.
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