Neurol. praxi. 2022;23(6):504-506 | DOI: 10.36290/neu.2021.091

Cortico-responsive encephalopathy as a complication of autoimmune thyroiditis

MUDr. Kateřina Dvorníková¹, MUDr. Jana Slonková, Ph.D.^{1, 2}, doc. MUDr. Ondřej Volný, Ph.D.^{1, 2}, MUDr. Jana Horáková¹, prof. MUDr. Michal Bar, Ph.D.^{1, 2}

¹ Neurologická klinika, Fakultní nemocnice Ostrava

² Katedra klinických neurověd, Lékařská fakulta Ostravská univerzita

Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare syndrome characterised by neuropsychiatric symptoms, high antithyroid antibodies and rapid clinical response to corticosteroids. We present a case of a patient admitted for hospitalisation for acute disorientation, perceptive speech disorder and incoherence of thinking, with a history of hyperthyreosis without recent concomitant therapy. CT and MRI brain scans were not diagnostically conclusive. Thyroid hormones and anti-thyroid antibodies were collected as part of a wider differential diagnosis. Anti-thyroid peroxidase (anti-TPO) antibodies were strongly positive. To treat the encephalopathy, related to autoimmune thyroid damage, intravenous methylprednisolone 1000 mg was newly introduced to the medication with clinical recovery ad integrum second day of application.

Keywords: encephalopathy, autoimmune thyroiditis, corticosteroids.

Received: September 1, 2021; Revised: November 7, 2021; Accepted: November 11, 2021; Prepublished online: November 11, 2021; Published: December 2, 2022  Show citation