Neurol. praxi. 2023;24(2):140-144 | DOI: 10.36290/neu.2022.059

Molecular and cellular biology of multiple sclerosis

RNDr. Kateřina Klíčová1, prof. MUDr. Jan Mareš, Ph.D., MBA1, MUDr. Jiří Bučil2
1 Neurologická klinika FN a LF UP Olomouc
2 Affidea Praha, s. r. o.

Multiple sclerosis is a chronic autoimmune inflammatory disease of the central nervous system with an unclear prognosis, mainly affecting young adults. It is a disease that is highly heterogeneous. The causes are multifactorial and include genetic predisposition along with environmental factors. Specific epigenetic modifications such as DNA methylation can affect the pathophysiology and key aspects of multiple sclerosis. Processes at the molecular level could be helpful in understanding the nature of the disease and setting up appropriate treatment for patients.

Keywords: DNA methylation, epigenetics, multiple sclerosis, molecular approaches to treatment.

Received: May 9, 2022; Revised: September 8, 2022; Accepted: September 29, 2022; Prepublished online: September 29, 2022; Published: April 21, 2023  Show citation

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Klíčová K, Mareš J, Bučil J. Molecular and cellular biology of multiple sclerosis. Neurol. praxi. 2023;24(2):140-144. doi: 10.36290/neu.2022.059.
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