Neurol. praxi. 2024;25(2):108-115 | DOI: 10.36290/neu.2023.084

Markers of neurodegenerative dementias: the contribution of neuroimaging and neurophysiological methods

David Ondráček^{1, 3}, Mgr. Žaneta Železníková^{1, 2}, MUDr. Zuzana Balážová, Ph.D.¹, Ing. Martin Lamoš, Ph.D.¹, prof. MUDr. Irena Rektorová, Ph.D.^{1, 2}

¹ Středoevropský technologický institut - CEITEC, Centrum neurověd, Masarykova univerzita, Brno

² 1. neurologická klinika, LF MU a FN u sv. Anny, Brno

³ Lékařská fakulta Masarykovy univerzity, Brno

There has been a great development in imaging methods and their use for early diagnosis of neurodegenerative disorders. The aim is to discover more sensitive biomarkers that would enable early stratification of dementia subtypes and disease prognosis. There are various types of imaging methods such as nuclear medicine (SPECT, PET), MRI and electrophysiology (EEG), which provide complementary picture about degenerative diseases. The main purpose of this work is to review the most typical findings in neurodegenerative dementia and their most common variants and subtypes. Although some of them are suitable only for scientific purposes, many have been utilized in diagnostic guidelines.

Keywords: SPECT, PET, MRI, EEG, neurodegenerative disorders, Alzheimer's disease, dementia with Lewy bodies, mild cognitive impairment.

Received: November 30, 2023; Revised: December 24, 2023; Accepted: December 29, 2023; Prepublished online: December 29, 2023; Published: April 16, 2024  Show citation