Slovo úvodem

prof. MUDr. Ivan Rektor, CSc., FCMA, FANA

Neurol. praxi. 2014;15(1):3  

Funkční zobrazovací metody v neurologii a neurochirurgii

prof. MUDr. Milan Brázdil, Ph.D. – editor hlavního tématu

Neurol. praxi. 2014;15(1):10  

Clinical use of functional magnetic resonance imaging (fMRI) when operating on brain tumours in the primary motor area

MUDr. Robert Bartoš, Ph.D., doc. MUDr. Robert Jech, Ph.D., prof. MUDr. Josef Vymazal, DrSc., prof. MUDr. Pavel Petrovický, DrSc., MUDr. Michal Orlický, prof. MUDr. Martin Sameš, CSc.

Neurol. praxi. 2014;15(1):11-15  

The article explains the principle and methodology of functional magnetic resonance imaging in localizing the primary motor cortex. The explanation of fMRI principles is followed by focusing on our own group of 18 patients in whom the reliability of fMRI was evaluated in comparison with a conventional method – electrical cortical stimulation. In conclusion, we propose some fundamental rules for how to proceed when functionally examining and operating on brain tumours in the motor area.

Use of positron emission tomography in neurology

MUDr. Irena Doležalová, MUDr. Karol Bolčák, prof. MUDr. Robert Kuba, Ph.D.

Neurol. praxi. 2014;15(1):16-21  

Positron emission tomography (PET) is an imaging technique providing information on the function of a certain tissue or organ. It is primarily used in oncology, neurology, and cardiology. The present review briefly explains the principle of PET examination and subsequently deals with its use in neurology. The main focus is on the fields of neuro-oncology and epileptology, i.e. on indications in which PET is commonly utilized clinically. Also mentioned are the options of its application in diagnosing extrapyramidal diseases, dementias, and cerebral infarctions; in these indications, PET is largely limited to the field of research.

Clinical use of SPECT in neurology

doc. MUDr. Petr Marusič, Ph.D., MUDr. Kateřina Zárubová, MUDr. Aleš Tomek

Neurol. praxi. 2014;15(1):22-25  

In neurological diagnostics, Single Photon Emission Computed Tomography (SPECT) is used only in a limited number of indications, mainly: 1) in presurgical assessment of refractory epilepsy patients, 2) in differential diagnostics of parkinsonian syndrome, 3) to assess functional cerebrovascular reserve in patients with internal carotic or intracerebral artery stenosis.

Multimodal approach in functional brain neuroimaging

MUDr. Martin Pail, Ph.D., MUDr. Petr Mikulenka, Ing. Radek Mareček, Ing. Michal Mikl, Ph.D., prof. MUDr. Milan Brázdil, Ph.D.

Neurol. praxi. 2014;15(1):26-30  

Due to the complex and complicated system as the human brain is, it is inconceivable that information contained in one modality (one physiological parameter) might absolutely and meaningfully describe all of the aspects of this system. For that reason in recent time there is an attempt to employ the intergration of analysis using diverse modalities with each other and so achieve better and complex insight into the whole system leading to comprehension of the human brain functioning.

Treatment of multiple sclerosis in Czech Republic - options and reality

MUDr. Michal Dufek

Neurol. praxi. 2014;15(1):31-35  

Treatment options in multiple sclerosis have expanded considerably in the recent years. In 2013, several new effective drugs were registered and more will be introduced in therapeutic practice in the coming years. However, the availability of drugs is limited due to restrictions of health care payers. Reimbursement regulations are often in conflict with evidence-based medicine. This article deals with both the good prospects in treating multiple sclerosis including an overview of new drugs and the current situation in the Czech Republic. The article presents specific cases of discrepancy between therapeutic options and the clinical reality.

Neurological complication of undetected vitamin B12 deficiency in Crohn΄s diseases

MUDr. Darina Petrleničová, PhD., MUDr. Katarína Kračunová, PhD., doc. MUDr. Peter Valkovič, PhD.

Neurol. praxi. 2014;15(1):36-38  

Patient´s with Crohn´s disease (CD) who have terminal ileal resections are at risk for vitamin B12 malabsorbtion. Neurological symptoms include peripheral polyneuropathy, but the progression of the patological process may cause development of serious degenerative brain and spinal cord changes. Typical neurological manifestation is the subacute combined degeneration of the spinal cord. We present a case of a patient with CD and heavy vitamin B12 deficiency neurological manifestation. We want to call attention to the importance of prevention and screening of individuals with the B12 deficiency predisposition.

Transcranial sonography with Parkonson΄s syndrome

MUDr. Monika Jelínková, doc. MUDr. David Školoudík, Ph.D., FESO, MUDr. Petra Bártová, Ph.D., prof. MUDr. Petr Kaňovský, CSc.

Neurol. praxi. 2014;15(1):39-42  

The authors present possibilities of the use of transcranial sonography of brain parenchyma in patients with movement disorders. In the article is described the technique of examination, technical parameters and sonographic findings in patients with Parkinson´s disease, multiple-system atrophy, progressive supranuclear palsy and corticobasal degeneration. supranuclear palsy, corticobasal degeneration, substantia nigra, nucleus lenticularis, nucleus caudate, brainstem raphe.

Selection of patients with normal pressure hydrocephalus for shunt placement

MUDr. Václav Vybíhal, Ph.D., MUDr. Ing. Tomáš Svoboda, MUDr. Karel Máca, Ph.D., MUDr. Marek Sova, MUDr. George Hanoun, prof. MUDr. Martin Smrčka, Ph.D., MBA, PhDr. Radka Neužilová Michalčáková, Ph.D.

Neurol. praxi. 2014;15(1):43-46  

Introduction: The authors present the possibility of using lumbar infusion test and external lumbar drainage in patients with normal pressure hydrocephalus to select patients for shunt placement. Material and methods: 82 patients were indicated for the shunt implantation from 2003 to 2011. Their mean age was 66.8 years. The group included 44 (53.7 %) men and 38 women (46.3 %). Patients were tested by lumbar infusion test in 77 cases, by external lumbar drainage in 22 patients, and both the above mentioned tests were carried out in 17 subjects. Results: Lumbar infusion test predicted correctly the effect of the surgery in 78.3 % and external lumbar...

Diflunisal - nová možnosť účinnej farmakologickej liečby familiárnej amyloidnej polyneuropatie?

doc. MUDr. Peter Špalek, PhD.

Neurol. praxi. 2014;15(1):52  

Practical experience with zonisamide in childhood and adolescence

MUDr. Michal Ryzí, doc. MUDr. Hana Ošlejšková, Ph.D.

Neurol. praxi. 2014;15(1):47-51  

In comparison with adults approved options of antiepileptic treatment in children are limited. The process of introduction of new antiepileptic drug is often longer. The aim of this review is to present comprehensive information concerning zonisamide in new indication – add-on therapy of partial seizures in children older than 6 years. The results of multicentric, double blind, placebo controled study and results of open label studies about safety and tolerability are presented. These findings are accompanied by authors´ experience.

Sympózium praktickej neurológie Neurológia pre prax, 18.-19. október 2013, Tatranská Lomnica

doc. MUDr. Vladimír Donáth, CSc.

Neurol. praxi. 2014;15(1):54