Neurol. pro Praxi, 2007; 3: 180-183

Primárna progresívna afázia – zriedkavá alebo poddiagnostikovaná

MUDr. Stanislav ©utovský, Mgr. Martin Malík, prof. MUDr. Pavel Traubner, PhD., prof. MUDr. Peter Turčáni, PhD.
I. neurologická klinika FNsP, Bratislava

Primárna progresívna afázia (PPA) je neurodegeneratívne ochorenie, ktoré je klinicky charakterizované progresívnym vývojom poruchy reči, spočiatku charakteru eferentnej motorickej afázie, pričom s progresiou ochorenia sa pridruľuje aj porucha senzorickej zloľky. Ochorenie končí mutizmom, »aľkým dementným syndrómom a akinézou. Priemerné preľívanie pacientov od začiatku prvých príznakov ochorenia je 5 rokov. Didakticky je primárna progresívna afázia spolu s frontotemporálnou demenciou a sémantickou demenciou, ktoré vąak majú rozdielny klinický obraz aj patologicko-anatomickú topografiu včlenená do súboru nazývaného Frontotemporálna lobárna degenerácia (FTLD) alebo Pickov komplex. Patologicko-anatomicky (topograficky) je PPA charakterizovaná asymetrickou atrofiou mozgu s výraznou prevahou v dominantnej hemisfére (najčastejąie µavej). Prináąame kazuistiky troch pacientov s progresívnou poruchou reči a s pridruľeným vývojom demencie, uzavretými ako primárna progresívna afázia.

Keywords: primárna progresívna afázia, Pickov komplex, frontotemporálna lobárna degenerácia, tau proteín

Published: August 1, 2007  Show citation

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©utovský S, Malík M, Traubner P, Turčáni P. Primárna progresívna afázia – zriedkavá alebo poddiagnostikovaná. Neurol. praxi. 2007;8(3):180-183.
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