Neurol. praxi. 2018;19(3):224-228 | DOI: 10.36290/neu.2018.098
Quality of life of patients following surgery for pharmacoresistant epilepsy
- 1 Centrum pro Epilepsie Brno Fakultní nemocnice u sv. Anny v Brně a Masarykovy univerzity v Brně
- 2 Neurochirurgická klinika, Fakultní nemocnice u sv. Anny v Brně
- 3 Středoevropský technologický institut (CEITEC), Brno
- 4 I. patologicko-anatomický ústav, Fakultní nemocnice u sv. Anny v Brně
Objective: The aim of the study was to ascertain in what way epilepsy surgery treatment affects the quality of life of patientsoperated on for pharmacoresistant epilepsy.
Method: Patients operated on for pharmacoresistant epilepsy completed a quality of life questionnaire (Quality of Life in EpilepsyInventory-89; QOLIE-89) before and after the surgery. QOLIE-89 evaluates the quality of life in 17 subscales, including the assessmentof overall quality of life using the total score. We statistically evaluated whether a change in the quality of life had occurredafter the surgery. Subsequently, the QOLIE-89 results were correlated with patient demographic data, including their IQ scoresand psychiatric/somatic comorbidities.
Results: The study included a total of 95 patients after resection epilepsy surgery who fully and correctly completed the questionnaireprior to and at least one year after the surgery. A statistically significant improvement occurred in the following subscales:health perceptions (p < 0.001), change in health (p < 0.001), general health (p < 0.001), work/driving/social function (p < 0.001), seizure worry (p < 0.001), health discouragement (p = 0.049), medication effects (p = 0.002), and overall quality of life (p = 0.001).Following surgery, a statistically significant improvement in the total score (p = 0.008) was found. No statistically significant correlationwas observed between the total score and demographic data.
Conclusion: Based on our questionnaire study it can be concluded that, in the majority of patients, epilepsy surgery treatmentnot only leads to elimination of seizures, but also significantly contributes to improved quality of life.
Keywords: epilepsy, pharmacoresistance, epilepsy surgery, quality of life, seizure freedom
Published: July 1, 2018 Show citation
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References
- Birbeck GL, Hays RD, Cui X, Vickrey BG. Seizure reduction and quality of life improvements in people with epilepsy. Epilepsia 2002; 43(5): 535-538.
Go to original source... - Brázdil M. Proměny epileptochirurgie ve 21. století. Neurol. Praxi 2015; 16(2): 77-79.
- Cunha I, Oliveira J. Quality of life after surgery for temporal lobe epilepsy: A 5-year follow up. Epilepsy Behav 2010; 17(4): 506-510. Go to original source...
- Engel J. Finally, a randomized, controlled trial of epilepsy surgery. N Engl J Med 2001; 345: 365-367. Go to original source...
- Englot DJ, Rolston JD, Wright CW, Hassnain KH, Chang EF. Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy. Neurosurgery 2016; 79(3): 345-353. Go to original source...
Go to PubMed... - Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Hauser WA, Mathern G, Moshe SL, Perucca E, Wiebe S, French J. Definition of drug resistant epilepsy: consensus proposal by the ad hoc task force of the ILAE Commission on Therapeutic Strategies. Aktuel Neurol 2010; 37(8): 372-381. Go to original source...
- Preiss J, Vojtěch Z. Kvalita života po resekční operaci pro farmakorezistentní epilepsii. Čes Slov Psychiat. 2007; 103(41): 175-183.
- Seiam A-HR, Dhaliwal H, Wiebe S. Determinants of quality of life after epilepsy surgery: Systematic review and evidence summary. Epilepsy Behav 2011; 21(4): 441-445. Go to original source...
- Spencer S, Huh L. Outcomes of epilepsy surgery in adults and children. Lancet Neurology 2008; 7(6): 525-537. Go to original source... Go to PubMed...
- Tlusta E, Kubena A, Salek S, Vlcek J. Psychometric properties of the Czech version of the Quality of Life in Epilepsy Inventory (QOLIE-31). Epilepsy Behav 2007; 10(3): 407-411. Go to original source...
- Tlusta E, Zarubova J, Simko J, Hojdikova H, Salek S, Vlacek J. Clinical and demographic characteristics predicting QOL in patients with epilepsy in the Czech Republic: How this can influence practice. Seizure 2009; 18(2): 85-89. Go to original source...
- Wiebe S, Blume WT, Girvin JP, Eliasziw M, for the Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med 2001; 345: 311-318. Go to original source...