Neurol. praxi. 2018;19(5):350-358 | DOI: 10.36290/neu.2018.117

Natural course of multiple sclerosis could be positively intervened by optimal nutrition

prof. RNDr. Jan Krejsek, CSc.

Ústav klinické imunologie a alergologie, LF UK a FN Hradec Králové

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of the central nervous systeme. It is characterizedby the loss of the homeostatic regulations of the immune systeme comprising both innate and specific T cell mediatedimmunity resulting in the abnormal functional polarisation of T cells into Th17 and Th1 subsets together with the participation ofabnormal B cells. Drugs used in clinical practice are targeting different steps of the inflammatory immunopathological process.The effect of this treatment could be enhanced by the optimal life style of MS patients. The inflammation in MS patients couldbe simply targeted by optimal nutrition. The special emphasize should be paid to the optimalisation of the gut microbiota. Thenutrition should be enriched for all components modulating inflammation in MS patients. These comprise vitamine D, vitamineB, vitamine C, polyunsaturated fatty acids, prebiotics, probiotics and the substances of herbal origin, especially polyphenols.

Keywords: multiple sclerosis, inflammation, neurodegeneration, nutrition, microbiota, vitamins, fatty acids, prebiotics, probiotics, polyphenols

Published: October 1, 2018  Show citation