Slovo úvodem

prof. MUDr. Ivan Rektor, CSc., FCMA, FANA

Neurol. praxi. 2018;19(1):3  

Epilepsie! Operovat?

prof. MUDr. Milan Brázdil, Ph.D. – editor hlavního tématu

Neurol. praxi. 2018;19(1):10 | DOI: 10.36290/neu.2018.072  

Pediatric epileptosurgery – special considerations and current trends

MUDr. Ondřej Horák

Neurol. praxi. 2018;19(1):11-15 | DOI: 10.36290/neu.2017.027  

Possibilities of modern epilepsy surgery offer help to most patients with drug-resistant epilepsy. The new surgical techniques,extending arsenal of epilepsy surgery procedures and still increasing quality of presurgical evaluation enable successful surgicalsolution of more complicated patients, not only in adulthood, but also in childhood. There is a clear worldwide trend, not onlyin increase of resections in MRI-nonlesional and extratemporal patients, but also in proportional growth of epilepsy surgery approachesin childhood, including the youngest age bracket. The aim of epilepsy surgery in children is not merely seizure reduction,but also arrangement...

Resective epilepsy surgery

prof. MUDr. Petr Marusič, Ph.D.

Neurol. praxi. 2018;19(1):16-21 | DOI: 10.36290/neu.2018.004  

Epilepsy surgery is the most effective way to achieve long-term seizure freedom in patients with drug-resistant focal epilepsy.Advances in neuroimaging investigations and development of methods for data postprocessing have increased the possibilityof accurately localizing the epileptogenic zone, particularly in patients with normal MRI. The need for invasive brain recordingsremains unchanged, with increasing proportion of stereo-EEG to target deep foci. Multi-modal co-registration may yield improvedguidance of resection. Surgeries performed in recent period were more likely to yield a favorable outcome, and improvementwas more marked in extratemporal...

Stereotactic epilepsy surgery

doc. MUDr. Zdeněk Vojtěch, Ph.D., MBA

Neurol. praxi. 2018;19(1):22-27 | DOI: 10.36290/neu.2018.073  

The reason for introduction of novel therapies in epilepsy surgery is invasiveness and adverse effects of existing therapies. Inclinical epileptology, radiosurgical, radiofrequency, laser, and ultrasound ablations have been used. The article summarizescontemporary literary data and, in case of radiosurgery and radiofrequency ablations, personal experience with these methods.

Neurostimulation in treating pharmacoresistant epilepsy

prof. MUDr. Milan Brázdil, Ph.D.

Neurol. praxi. 2018;19(1):28-31 | DOI: 10.36290/neu.2018.074  

The contemporary care of patients with pharmacologically unmanageable epilepsy increasingly involves the use of neurostimulationmethods. The reason is an entirely legitimate effort to offer a substantially better quality of life even in those in whomresection epilepsy surgery is not suitable for serious reasons. In the case of neurostimulation, palliative interventions are used,i.e. their goal is to at least significantly reduce the number of seizures, particularly those where there is a risk of injury. Althoughcomplete suppression of seizures is relatively rare with their use, standard neurostimulation techniques have been shown to havelong-term efficacy...

Classification of the epileptic seizures and classification of the epilepsies ILAE 2017

prof. MUDr. Petr Marusič, Ph.D., doc. MUDr. Hana Ošlejšková, Ph.D., prof. MUDr. Milan Brázdil, Ph.D., MUDr. Klára Brožová, MUDr. Jan Hadač, Ph.D., doc. MUDr. Jiří Hovorka, CSc., prof. MUDr. Vladimír Komárek, CSc., prof. MUDr. Pavel Kršek, Ph.D., prof. MUDr. Ivan Rektor, CSc., MUDr. Martin Tomášek, doc. MUDr. Zdeněk Vojtěch, Ph.D., MBA, MUDr. Jana Zárubová

Neurol. praxi. 2018;19(1):32-36 | DOI: 10.36290/neu.2018.075  

Following the discussion at all levels, ILAE Commission for Classification and Terminology has published in 2017 two position papers onclassification of the epileptic seizures and on classification of the epilepsies. In the text we present translation of some parts of the originalposition papers and the Czech version of the terminology and classification that is recommended by the Czech League against Epilepsy.

Immunoadsorption in treating neurological diseases

MUDr. Jiří Piťha

Neurol. praxi. 2018;19(1):37-40 | DOI: 10.36290/neu.2018.076  

In recent years, immunoadsorption has become an increasingly recognized alternative to therapeutic plasmapheresis used totreat neurological diseases, such as Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, myastheniagravis, neuromyelitis optica and its spectrum disorders, multiple sclerosis, or autoimmune encephalitides. In contrast to therapeuticplasmapheresis that requires plasma exchange with albumin or fresh-frozen plasma, immunoadsorption is a technique allowingselective removal of humoral factors, primarily of pathological autoantibodies, with a high-affinity adsorbent. This therapeuticmethod has fewer adverse effects...

Low back pain in the elderly

MUDr. Tereza Andrašinová, MUDr. Eva Kalíková, doc. MUDr. Blanka Adamová, Ph.D.

Neurol. praxi. 2018;19(1):41-47 | DOI: 10.36290/neu.2018.011  

Low back pain (LBP) is one of the most common disabling conditions among adults 60+ years old. The severity and chronicity ofthis clinical syndrome clearly increase with age. The annual prevalence of LBP in the elderly population ranges between 13–50%.Pain is usually caused by functional and non-specific degenerative changes of the spine, but in the elderly population the differenttypes of pathology such as osteoporotic fractures, spinal tumors, or infections, may play a role. Diagnostic procedure should befocused on detection of symptoms of serious spinal pathology, called "red flags". Insufficient pain treatment may lead to sleepdisturbances,...

Application of determination of free light chains of immunoglobulins in the diagnosis of multiple sclerosis

Mgr. Ľubica Jesenská, MUDr. Daniel Čierny, PhD., MUDr. Lenka Plicová, prof. MUDr. Dušan Dobrota, CSc.

Neurol. praxi. 2018;19(1):53-58 | DOI: 10.36290/neu.2019.073  

This work gives a brief review of the markers used in the laboratory diagnosis of multiple sclerosis. We focus on the determinationof free light chains of immunoglobulins and its possible application in the process of diagnosis of multiple sclerosis.

Multiple brain abscesses within meningoencephalitis of unknown etiology

MUDr. Jana Horáková, MUDr. Pavel Ressner, Ph.D., doc. MUDr. Michal Bar, Ph.D.

Neurol. praxi. 2018;19(1):59-62 | DOI: 10.36290/neu.2018.001  

Brain abscess is defined as purulent and inflammation region within brain parenchyma. We present a case report of a 44-yearsoldman who was urgently received at the Neurological Clinic of University Hospital Ostrava for acute headache. This headachebegan after coughing. CT scan including angiography excludes the diagnosis of subarachnoid hemorrhage. Episode of epilepticseizure appeared quickly after admission to the hospital. We made lumbar puncture, where was typical cytological picture ofacute inflammation. We thinking about possible meningoencephalitis, so broad-spectrum antibiotics was used. Deteriorationof the condition appeared in the further...

Anti CD20 multiple sclerosis therapy

doc. MUDr. Pavel Štourač, Ph.D.

Neurol. praxi. 2018;19(1):49-52 | DOI: 10.36290/neu.2018.077  

The efficacy of multiple sclerosis therapy by monoclonal anti- CD 20 antibodies was confirmed in clinical trials. Three monoclonalantibodies ocrelizumab, rituximab and ofatumumab are effective. The efficacy of ocrelizumab was shown in relaps-remitting andprimary progressive course of multiple sclerosis and broadens the spectrum of multiple sclerosis therapy. In primary progressivecourse of multiple sclerosis ocrelizumab is the only effective therapy until now.

Kognitivní rehabilitace

PhDr. Petr Nilius, Ph.D., Mgr. et Mgr. Tomáš Nikolai, Ph.D.

Neurol. praxi. 2018;19(1):65-66  

Jak se postupuje v případě omezení svéprávnosti u nemocného s Alzheimerovou chorobou?

Neurol. praxi. 2018;19(1):73-74  

Neurozobrazovací kazuistika

MUDr. Martin Pail, Ph.D., MUDr. Marta Pažourková, prof. MUDr. Milan Brázdil, Ph.D.

Neurol. praxi. 2018;19(1):63-64 | DOI: 10.36290/neu.2018.078  

Josef Gerstmann (1887–1969)

MUDr. Petra Divišová, prof. MUDr. Petr Kaňovský, CSc.

Neurol. praxi. 2018;19(1):70-71