Slovo úvodem

prof. MUDr. Ivan Rektor, CSc.

Neurol. praxi. 2016;17(2):71  

Funkční poruchy hybnosti - slovo úvodem

prof. MUDr. Jan Roth, CSc., MUDr. Tereza Serranová, Ph.D.

Neurol. praxi. 2016;17(2):78 | DOI: 10.36290/neu.2016.015  

Functional movement disorders: a general overview

MUDr. Tereza Serranová, Ph.D.

Neurol. praxi. 2016;17(2):79-86 | DOI: 10.36290/neu.2016.016  

Functional (psychogenic) movement disorders are characterized variability and inconsistency of the symptoms, which are incongruent with movement disorders known to be caused by organic neurological disease. The pathophysiology of functional movement disorders is still poorly understood. Previously emphasized causal role of psychological factors was questioned and a neurobiological model of the development of functional symptoms has been proposed. The diagnosis of functional movement disorders should rely on the presence of characteristic clinical features and not on exclusion of organic causis. Early diagnosis and its acceptance by the patient, is...

Physiotherapy for functional movement disorders

Bc. Dana Fialová, MUDr. Tereza Serranová, Ph.D.

Neurol. praxi. 2016;17(2):87-91 | DOI: 10.36290/neu.2016.017  

Physiotherapy has a key role in the multidisciplinary management of patients with functional motor disorder (FMD). Despite growing evidence that physiotherapy is an effective treatment, we still lack evidence-based guidelines on what physiotherapy for FMD should consist of. Here we present recommendations for approach towards patients with FMD and physiotherapy that have been successful in FMD and which are based on existing evidence and experience from leading experts in this field. Physiotherapy should address self-directed attention and abnormal habitual movement patterns through a process of education, movement retraining and self-management strategies.

Psychosomatic approach to functional movement disorders

MUDr. Ondřej Masner

Neurol. praxi. 2016;17(2):92-94 | DOI: 10.36290/neu.2016.018  

Functional movement disorders (FMD) are challenging diagnoses not only for the physician, but also for the patient. The complexity of the symptoms and their complicated classification is usually causing significant uncertainty and is a burden for the relationship between patient and physician. Psychosomatic approach can significantly improve the outcome of FMD by extending the focus from the somatic level only, to psychological and social context, thus accomplishing their integration. This may enable the patient to access psychosocial factors, which may be obstructing the clinical improvement. The complexity of development and maintenance of FMD is...

Glatiramer acetate: long-term immunomodulatory therapy in multiple sclerosis - safety, efficacy,

MUDr. Olga Zapletalová

Neurol. praxi. 2016;17(2):95-99 | DOI: 10.36290/neu.2016.019  

adherence and persistence assesment Glatiramer acetate, an immunomodulatory drug which has long been used in the treatment of multiple sclerosis in the phase of a clinically isolated syndrome and relapsing- remitting course. The etiopathogenesis of multiple sclerosis are included in both the innate and heterogeneous immune inflammatory mechanisms and creeping neurodegenerative changes. Expected therapeutic effect of Glatiramer acetate is an anti-inflammatory and neuroprotective. It is approved as first-line drug in 57 countries, and its exposure is over 20 years of continuous clinical use and monitoring. Its effect upon the early treatment of clinically...

Role of T and B cells in pathogenesis of multiple sclerosis

MUDr. Zbyšek Pavelek, prof. RNDr. Jan Krejsek, CSc., doc. MUDr. Martin Vališ, Ph.D.

Neurol. praxi. 2016;17(2):100-103 | DOI: 10.36290/neu.2016.020  

Multiple sclerosis is a chronic inflammatory demyelinating disease which affect central nervous system. This autoimmune disease manifests itself with various symptoms. This review explore the principle features of the immunopathology of multiple sclerosis. This include a role of T cells, B cells and cytokine netwoks promoting damage of the tissue. As the etiology of multiple sclerosis is unknown, available agents modify the disease course. Fundamental appreciation of the immmunopathology of multiple sclerosis leads to a broader understanding to mechanism of the agents, that are mentioned.

Sporadic form of meningioangiomatosis

MUDr. Pavel Řehulka, prof. MUDr. Robert Kuba, Ph.D., prof. MUDr. Markéta Hermanová, Ph.D., Alona Chasovskykh, prof. MUDr. Milan Brázdil, Ph.D.

Neurol. praxi. 2016;17(2):104-107 | DOI: 10.36290/neu.2016.021  

Meningioangiomatosis is a rare, benign lesion characterized by focal vascular and cellular proliferation of leptomeninges and adjacent cortex. Sporadic form of this desease may manifest by epileptic seizures. We present literature review on intractable epilepsy caused by sporadic form of meningioangiomatosis.

Development of socio-economic status in patients with PAS over the years

MUDr. Zuzana Juříková, MUC. Martina Jambrikovičová, doc. MUDr. Hana Ošlejšková, CSc.

Neurol. praxi. 2016;17(2):108-112 | DOI: 10.36290/neu.2016.022  

Autism is one of the most serious, lifelong disorder of children's mental development, mostly requiring lifelong care of another person. The ability to predict the outcome (development of the disorders in adulthood and economic involvement of individuals in adulthood) of children with autism, so lets families plan the future of their children and create reasonable expectations. Studies, which follow up socio-economic status (SES) in adults through almost 50 years, are compared in this article. In addition we deal with scores, which can be used for outcome in adults, so single studies could be compared. We also think about factores, which influence...

Treatment of neuropathic pain

MUDr. Marek Hakl, Ph.D.

Neurol. praxi. 2016;17(2):113-116 | DOI: 10.36290/neu.2016.023  

Neuropathic pain is one of the most difficult-to-treat pain conditions. Numerous common analgesics are not effective in treating it. Drugs from the groups of anticonvulsants, antidepressants, opioids with an increased affinity to neuropathic pain, and, recently, new topical dosage forms have been at the forefront of treatment. The occurrence of neuropathic pain increases exponentially with patient age; at the same time, however, tolerance of patients to antineuropathic treatment decreases. A major benefit in treating neuropathic pain has been the development of uniform EFNS guidelines based on which national guidelines are subsequently developed. The...

Lumbar spinal stenosis or amyotrophic lateral sclerosis?

doc. MUDr. Blanka Adamová, Ph.D., MUDr. Iva Šrotová, MUDr. Jakub Stulík

Neurol. praxi. 2016;17(2):117-122 | DOI: 10.36290/neu.2016.024  

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive impairment of upper and lower motor neurons. The typical sign of ALS is focal onset. The differential diagnosis of ALS, especially in the early stage of the disease when clinical and electrophysiological abnormalities are not fully developed, is wide. We present a case report that describes mistaking diagnosis of ALS in early stage for lumbar spinal stenosis that resulted in not indicated surgery. This case report emphasises the necessity of careful evaluation of degenerative impairment of spine as the main cause of neurological problems.

Chronic subdural haematoma associated with advanced malignant tumor

MUDr. Dušan Hrabovský, doc. MUDr.Radim Jančálek, Ph.D., prof. MUDr. Markéta Hermanová, Ph.D., MUDr. Petr Burkoň, Ph.D., doc. MUDr. Jan Chrastina, Ph.D.

Neurol. praxi. 2016;17(2):123-127 | DOI: 10.36290/neu.2016.025  

Unique case report of prostate cancer metastasis to the membranes of the chronic subdural haematoma The study aims to present the case of prostate cancer patient with generalised metastatic skeletal involvement with sudden deterioration into comatose status and gradual development of bilateral mydriasis caused by bilateral non homogenous chronic subdural haematoma. After emergency bilateral frontal trephinations another surgery for residual subdural haematoma in parietal region was performed. Histological study of the resected outer membrane of the chronic subdural haematoma showed prostate cancer infiltration. Metastatic disease affecting the outer...

Swinging London Doctor, or the Story of Richard Asher and Baron Münchhausen

prof. MUDr. Petr Kaňovský, CSc., MUDr. Kateřina Menšíková, Ph.D., prof. MUDr. Ing. Petr Hluštík, Ph.D.

Neurol. praxi. 2016;17(2):128-132  

Richard Asher, a London physician working as a consultant in the Middlesex Hospital, became famous in the field of neurology and neuropsychiatry by the description of Münchhausen syndrome and Hashimoto´s encephalopathy (the later he named “myxedematous madness“). Beside that, he became fanous for his journal essays, in which he tried to define the doctor-patient relationship and the common sense in medicine.

Sympózium praktickej neurológie Neurológia pre prax, IX. ročník, 25.-26. októbra, Tatranská Lomnica

doc. MUDr. Vladimír Donáth, CSc.

Neurol. praxi. 2016;17(2):134